<p>In this contribution we introduce a novel weak solution concept for two-phase volume-preserving mean curvature flow, having both properties of unconditional global-in-time existence and weak–strong uniqueness. These solutions extend the ones proposed by Hensel and Laux (J Differ Geom 130:209–268, 2025) for the standard mean curvature flow, and consist in evolving varifolds coupled with the phase volumes by a transport equation. First, we show that, in the same setting as in Takasao (Arch Ration Mech Anal 247:52, 2023), any sharp interface limit of solutions to a slightly modified nonlocal Allen–Cahn equation is a varifold solution according to our new definition. Secondly, we crucially introduce a new notion of volume-preserving gradient-flow calibrations, allowing the extended velocity vector field to point in the normal direction on the interface. We show that any sufficiently regular strong solution is calibrated in this sense. Finally, we prove that any classical solution to volume-preserving mean curvature flow, which is then automatically a calibrated flow, is unique in the class of our new varifold solutions.</p>