Scholarlink

<p>The gradual rise in global cancer rates every year instills the need for a reliable therapeutic strategy. Chemotherapy alone or in combination with surgery, radiation, or adjuvant therapy is still the preferred treatment option for a wide range of cancers. Doxorubicin (dox) is an extensively used chemotherapeutic anthracycline for combating a broad range of solid and soft-tissue tumors. However, dox therapy is often associated with undesirable side effects, mainly cardiotoxicity, limiting its clinical application. Over the years, many strategies have been developed to overcome these toxicities and improve the drug’s therapeutic potential. This review is focused on discussing the recent investigations into natural compounds, nanoformulations, miRNAs, and physical exercise in protecting against dox-mediated cardiotoxicity, hepatotoxicity, nephrotoxicity, and neurotoxicity.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A recent decade update on combating doxorubicin-induced toxicities

  • 期刊论文

  • 发表日期：

    2025年7月2日

查看全文
  • Sruthi Sritharan,
  • Nageswaran Sivalingam

摘要

The gradual rise in global cancer rates every year instills the need for a reliable therapeutic strategy. Chemotherapy alone or in combination with surgery, radiation, or adjuvant therapy is still the preferred treatment option for a wide range of cancers. Doxorubicin (dox) is an extensively used chemotherapeutic anthracycline for combating a broad range of solid and soft-tissue tumors. However, dox therapy is often associated with undesirable side effects, mainly cardiotoxicity, limiting its clinical application. Over the years, many strategies have been developed to overcome these toxicities and improve the drug’s therapeutic potential. This review is focused on discussing the recent investigations into natural compounds, nanoformulations, miRNAs, and physical exercise in protecting against dox-mediated cardiotoxicity, hepatotoxicity, nephrotoxicity, and neurotoxicity.