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<p>Recent events involving nerve agents of the A-Series, a once elusive class of chemical warfare agents, have provoked a great concern in the international community. In this paper, continuing our research efforts in Medicinal Chemistry at the&#xa0;Brazilian Institute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN) (an&#xa0;OPCW-designated Laboratory for environmental samples), we explore ANMP, an A-230 surrogate, in the search for new treatment options for intoxications caused by these chemicals. Five isatin-pyridine oxime hybrids were evaluated as acetylcholinesterase (AChE) reactivators using a modified Ellman’s assay. Our results indicate that monocationic hybrids with five methylene units, as well as its oxa-analog, are promising compounds for the design of new AChE reactivators.</p>

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In silico studies and in vitro evaluation of isatin-pyridine oxime hybrids as novel reactivators of acetylcholinesterase inhibited by an A-230 surrogate

  • 期刊论文

  • 发表日期：

    2025年3月4日

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  • Leandro B. Bernardo,
  • Leandro A. Vieira,
  • Caio V. N. Borges,
  • Pedro A. G. Buitrago,
  • Kamil Kuča,
  • Tanos C. C. França,
  • Samir F. A. Cavalcante,
  • Roberto B. Sousa,
  • Antônio L. S. Lima,
  • Daniel A. S. Kitagawa

摘要

Recent events involving nerve agents of the A-Series, a once elusive class of chemical warfare agents, have provoked a great concern in the international community. In this paper, continuing our research efforts in Medicinal Chemistry at the Brazilian Institute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN) (an OPCW-designated Laboratory for environmental samples), we explore ANMP, an A-230 surrogate, in the search for new treatment options for intoxications caused by these chemicals. Five isatin-pyridine oxime hybrids were evaluated as acetylcholinesterase (AChE) reactivators using a modified Ellman’s assay. Our results indicate that monocationic hybrids with five methylene units, as well as its oxa-analog, are promising compounds for the design of new AChE reactivators.