Scholarlink

<p>Two-component regulatory systems (TCSs) are ubiquitous signal transduction pathways in bacteria, enabling adaptive responses to environmental changes via phosphoryl signaling. In <i>Vibrio parahaemolyticus</i>, a globally significant enteropathogen, TCSs orchestrate survival strategies and pathogenicity. This review synthesizes current knowledge on the composition, signaling mechanisms, and functional roles of key TCSs in <i>V. parahaemolyticus</i>. Systems such as VbrK/VbrR, which senses β-lactams and nitrite to modulate β-lactamase production and suppresses type III secretion system 1 (T3SS1), and ArcB/ArcA, which integrates oxygen-dependent signals into quorum sensing and virulence regulation, highlight the adaptability of this pathogen. Other systems, including BarA/UvrY, PhoB/PhoR, and TtrS/TtrR, further illustrate the regulatory complexity governing metabolism, motility, and host colonization. Despite advances, significant gaps remain in understanding ligand specificity, cross-system interactions, and mechanistic details of transcriptional regulation, particularly for newly identified regulatory targets and auxiliary TCS interactions.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Overview of functionally characterized two-component regulatory systems in Vibrio parahaemolyticus

  • 期刊论文

  • 发表日期：

    2026年5月8日

查看全文
  • Fengjun Sun,
  • Pu Yao,
  • Yiquan Zhang

摘要

Two-component regulatory systems (TCSs) are ubiquitous signal transduction pathways in bacteria, enabling adaptive responses to environmental changes via phosphoryl signaling. In Vibrio parahaemolyticus, a globally significant enteropathogen, TCSs orchestrate survival strategies and pathogenicity. This review synthesizes current knowledge on the composition, signaling mechanisms, and functional roles of key TCSs in V. parahaemolyticus. Systems such as VbrK/VbrR, which senses β-lactams and nitrite to modulate β-lactamase production and suppresses type III secretion system 1 (T3SS1), and ArcB/ArcA, which integrates oxygen-dependent signals into quorum sensing and virulence regulation, highlight the adaptability of this pathogen. Other systems, including BarA/UvrY, PhoB/PhoR, and TtrS/TtrR, further illustrate the regulatory complexity governing metabolism, motility, and host colonization. Despite advances, significant gaps remain in understanding ligand specificity, cross-system interactions, and mechanistic details of transcriptional regulation, particularly for newly identified regulatory targets and auxiliary TCS interactions.