Scholarlink

<p>Among bacterial infections, urinary tract infections (UTIs) remain the most prevalent worldwide and are increasingly challenging to manage due to antibiotic resistance and recurrent inflammation. <i>Caryota mitis</i> L. (<i>C. mitis</i>), locally known as the Fishtail plant, has traditionally been used to treat various disease elements. It has been reported to possess antioxidant, antimicrobial, and anti-inflammatory properties; however, its use in treating UTI-associated pathogens and inflammation remains unexplored. Thus, we aimed to evaluate the anti-inflammatory and antibacterial potential of the methanol extract of <i>C. mitis</i> leaves. GC-MS was initially used for characterisation of <i>C. mitis</i> extract, followed by in-vitro anti-inflammatory (LPS-induced human urinary bladder epithelial T24 cells) and anti-bacterial activity against UTI pathogens (<i>E. coli</i>,<i> K. pneumoniae</i>,<i> Pseudomonas</i> spp., <i>Enterobacter</i> spp., and <i>Proteus mirabilis</i>) was investigated. The <i>C. mitis</i> extract significantly reduces levels of inflammatory cytokines and inhibits all tested uropathogens in a dose-dependent manner. This study highlights <i>C. mitis</i> as a promising adjunct natural therapeutic candidate for managing UTIs.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Anti-inflammatory and anti-bacterial potentials of Caryota mitis L. leaves extract in urothelial LPS-induced inflammation and UTI pathogens

  • 期刊论文

  • 发表日期：

    2026年3月14日

查看全文
  • Sandesh Kumar Pattanaik,
  • Sudipta Jena,
  • Diptirani Rath

摘要

Among bacterial infections, urinary tract infections (UTIs) remain the most prevalent worldwide and are increasingly challenging to manage due to antibiotic resistance and recurrent inflammation. Caryota mitis L. (C. mitis), locally known as the Fishtail plant, has traditionally been used to treat various disease elements. It has been reported to possess antioxidant, antimicrobial, and anti-inflammatory properties; however, its use in treating UTI-associated pathogens and inflammation remains unexplored. Thus, we aimed to evaluate the anti-inflammatory and antibacterial potential of the methanol extract of C. mitis leaves. GC-MS was initially used for characterisation of C. mitis extract, followed by in-vitro anti-inflammatory (LPS-induced human urinary bladder epithelial T24 cells) and anti-bacterial activity against UTI pathogens (E. coli, K. pneumoniae, Pseudomonas spp., Enterobacter spp., and Proteus mirabilis) was investigated. The C. mitis extract significantly reduces levels of inflammatory cytokines and inhibits all tested uropathogens in a dose-dependent manner. This study highlights C. mitis as a promising adjunct natural therapeutic candidate for managing UTIs.