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<p>Quorum sensing (QS) is a cell-density-dependent communication process that allows phytopathogenic bacteria to synchronise pathogenicity, mobility, secretion systems, and biofilm development. These signalling networks are pivotal in the progression of plant diseases and serve as promising targets for non-toxic anti-virulence approaches. Prominent quorum-sensing systems in plant-associated bacteria include acyl-homoserine lactone (AHL), diffusible signal factor (DSF), and virulence factor-modifying (VFM) pathways, each regulating distinct pathways involved in pathogenesis. The existing understanding of the molecular structure, signal production, perception, and subsequent control of these quorum-sensing systems in significant phytopathogens, including <i>Pseudomonas syringae</i>, <i>Ralstonia solanacearum</i>, <i>Agrobacterium tumefaciens</i>, <i>Burkholderia glumae</i>, and Dickeya spp., is consolidated. The focus is on quorum-quenching techniques, encompassing enzymatic signal degradation and the influence of natural quorum-sensing inhibitors sourced from plants and microbes, which interrupt communication while preserving bacterial survival. Recent advancements in biochemical characterisation, genomics, and nanotechnology-based delivery technologies are evaluated for their potential to enhance stability and field usability. Collectively, targeting QS-mediated control is a sustainable alternative to traditional agrochemicals, providing exciting opportunities for environmentally friendly approaches to controlling bacterial plant diseases.</p>

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A critical review of natural quorum-sensing inhibitors as molecular anti-virulence agents against phytopathogenic bacteria

  • 期刊论文

  • 发表日期：

    2026年2月2日

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  • Kayeen Vadakkan,
  • Kavya Santhosh Ponnathodi,
  • Rini Raphael,
  • Meena Kochappan Cheruvathur,
  • Preetha Remadevi,
  • Selvaraj Vijayanand

摘要

Quorum sensing (QS) is a cell-density-dependent communication process that allows phytopathogenic bacteria to synchronise pathogenicity, mobility, secretion systems, and biofilm development. These signalling networks are pivotal in the progression of plant diseases and serve as promising targets for non-toxic anti-virulence approaches. Prominent quorum-sensing systems in plant-associated bacteria include acyl-homoserine lactone (AHL), diffusible signal factor (DSF), and virulence factor-modifying (VFM) pathways, each regulating distinct pathways involved in pathogenesis. The existing understanding of the molecular structure, signal production, perception, and subsequent control of these quorum-sensing systems in significant phytopathogens, including Pseudomonas syringae, Ralstonia solanacearum, Agrobacterium tumefaciens, Burkholderia glumae, and Dickeya spp., is consolidated. The focus is on quorum-quenching techniques, encompassing enzymatic signal degradation and the influence of natural quorum-sensing inhibitors sourced from plants and microbes, which interrupt communication while preserving bacterial survival. Recent advancements in biochemical characterisation, genomics, and nanotechnology-based delivery technologies are evaluated for their potential to enhance stability and field usability. Collectively, targeting QS-mediated control is a sustainable alternative to traditional agrochemicals, providing exciting opportunities for environmentally friendly approaches to controlling bacterial plant diseases.