Scholarlink

<p>Quorum-sensing agonists significantly enhance biofilm formation and bioleaching efficiency. In this study, we synthesized acyl-homoserine lactone (AHL) analogs and investigated their effects on biofilm formation in <i>Acidithiobacillus thiooxidans</i>, mineral adsorption kinetics, and pentlandite bioleaching. The results showed that A-3 promoted biofilm formation, enhanced adsorption capacity toward pentlandite, and improved pentlandite bioleaching efficiency. Molecular docking revealed that A-3 exhibited higher binding affinity for the quorum-sensing receptor protein AfeR than its natural signaling ligand. In summary, compared to the natural signaling molecule, A-3 significantly enhanced biofilm formation and adsorption capacity, consequently improving bioleaching efficiency. This establishes a theoretical foundation for optimizing bioleaching in industrial applications.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Synthesis of N-acyl-homoserine lactones analogs for improving the potential application of Acidithiobacillus thiooxidans in bioleaching

  • 期刊论文

  • 发表日期：

    2025年9月20日

查看全文
  • Deping Tang,
  • Mengjiao Li,
  • Wentao Song,
  • Yanpeng Xi,
  • Yali Liu,
  • Yanyan Lin,
  • Hao Feng,
  • Aihong Mao

摘要

Quorum-sensing agonists significantly enhance biofilm formation and bioleaching efficiency. In this study, we synthesized acyl-homoserine lactone (AHL) analogs and investigated their effects on biofilm formation in Acidithiobacillus thiooxidans, mineral adsorption kinetics, and pentlandite bioleaching. The results showed that A-3 promoted biofilm formation, enhanced adsorption capacity toward pentlandite, and improved pentlandite bioleaching efficiency. Molecular docking revealed that A-3 exhibited higher binding affinity for the quorum-sensing receptor protein AfeR than its natural signaling ligand. In summary, compared to the natural signaling molecule, A-3 significantly enhanced biofilm formation and adsorption capacity, consequently improving bioleaching efficiency. This establishes a theoretical foundation for optimizing bioleaching in industrial applications.

Graphical abstract