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<p>The frequency of opportunistic fungal infections has been increasing, impacting agriculture, food, and health sectors. In this work, four thiosemicarbazone-chalcones (TC) were synthesized and evaluated by the radial diffusion method against filamentous fungi. All TCs were effective against <i>Aspergillus parasiticus</i>, especially the fluor-substituted one, with radial growth inhibition of 62,9% and 74,4% at the lower (0.209 µmol/ml) and highest (1.670 µmol/ml) concentrations tested, respectively. On the other hand, the non-substituted derivative was the most active against <i>A</i>. <i>carbonarius</i>, inhibiting radial growth by 47,9% and 74,1% at 0.222 µmol/ml and 1.777 µmol/ml, respectively. Additionally, the compounds were evaluated against the dimorphic fungi <i>Sporothrix brasiliensis</i>, <i>S. schenckii</i>, and a clinical strain of <i>Sporothrix spp</i>, exhibiting minimum inhibitory concentrations (MICs) in the range of 0.396–1.777 µmol/ml. When tested against four yeasts of the <i>Candida genus</i>, the thiosemicarbazone-chalcones demonstrated greater activity against <i>C. krusei</i> (MICs 0.011–0.026 µmol/ml).</p>

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Antifungal effects of thiosemicarbazone-chalcones on Aspergillus, Candida and Sporothrix strains

  • 期刊论文

  • 发表日期：

    2025年1月4日

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  • William Q. Felippe,
  • Igor R. Barbosa,
  • Aguida A. Oliveira,
  • Gisela L. da Costa,
  • Aurea Echevarria

摘要

The frequency of opportunistic fungal infections has been increasing, impacting agriculture, food, and health sectors. In this work, four thiosemicarbazone-chalcones (TC) were synthesized and evaluated by the radial diffusion method against filamentous fungi. All TCs were effective against Aspergillus parasiticus, especially the fluor-substituted one, with radial growth inhibition of 62,9% and 74,4% at the lower (0.209 µmol/ml) and highest (1.670 µmol/ml) concentrations tested, respectively. On the other hand, the non-substituted derivative was the most active against A. carbonarius, inhibiting radial growth by 47,9% and 74,1% at 0.222 µmol/ml and 1.777 µmol/ml, respectively. Additionally, the compounds were evaluated against the dimorphic fungi Sporothrix brasiliensis, S. schenckii, and a clinical strain of Sporothrix spp, exhibiting minimum inhibitory concentrations (MICs) in the range of 0.396–1.777 µmol/ml. When tested against four yeasts of the Candida genus, the thiosemicarbazone-chalcones demonstrated greater activity against C. krusei (MICs 0.011–0.026 µmol/ml).