<p>Blast wave mitigation is a critical issue whenever the protection of occupants and content within a structure is considered to avoid the destructive effects of explosive events at the structure exterior vicinity. This research focuses on louver systems mounted at the exterior window openings, aiming at evaluating their effectiveness in attenuating blast wave parameters, such as peak pressure and impulse, at the exterior building façade. A comprehensive numerical methodology was developed using an advanced CFD code to simulate blast propagation through louvers with specific geometric configurations under varying conditions of charge weight and scaled distance. The study focuses on the blast characteristics behind the louver and identifies significant spatial variability in attenuation effectiveness, emphasizing the importance of continuous spatial analysis rather than focusing on discrete point measurements. Symmetrical louver configurations demonstrated superior performance compared to asymmetrical designs, providing critical insights that may assist in optimizing mitigation solutions through further studies. Additionally, preliminary evaluations of the effect of the opening size within which the louver is installed revealed its impact on attenuation factors, warranting further dedicated research. A methodology for interpolation and extrapolation was proposed, enabling the estimation of attenuation factors for unexplored parameter combinations, significantly reducing computational effort. These findings contribute to significantly advancing the state of the art, enhancing the understanding of blast wave mitigation mechanisms, and illuminating the effectiveness of the examined louver-based protective solutions.</p>