Introduction and Hypothesis <p>Currently, there is a lack of comprehensive assessment regarding the burden of urinary tract infections (UTIs) among women of child-bearing age (WCBA), a distinct demographic group. The objective of this study is to analyze the epidemiological trends of UTIs in WCBA globally from 1990 to 2021.</p> Methods <p>Data of UTI incidence, prevalence and disability-adjusted life years (DALYs) were obtained from Global Burden of Disease 2021. The estimated annual percentage change, health inequality analysis and Bayesian age-period-cohort model were utilized for analyzing local trends, investigating health inequalities associated with the Socio-Demographic Index (SDI), and forecasting future epidemiological trajectories respectively.</p> Results <p>From 1990 to 2021, in WCBA, the global burden of UTIs showed an upward trend. There was significant heterogeneity in the UTI burden of WCBA among different regions and countries. In 2021, the number of incident cases was 217,843,782, the age-standardized incidence rate (ASIR) was 11,178.04, the number of prevalent cases was 4,142,002, the age-standardized prevalence rate was 212.54, the number of DALYs was 917,618, and the age-standardized DALYs rate (ASDR) was 47.08. The burden of ASDR was concentrated in countries with a lower SDI. It is projected that the burden of UTIs will continue to rise. The number of incident cases in 2036 will be 250,308,376 (ASIR 11,674.25).</p> Conclusions <p>The escalating burden of UTIs among WCBA constitutes a significant global public health challenge, necessitating enhanced management and control measures to achieve women’s health objectives, particularly in tropical and underdeveloped regions.</p>