Introduction and Hypothesis <p>We aimed to translate and validate the International Consultation on Incontinence Questionnaire Nocturia (ICIQ-N) and Nocturia Quality of Life (ICIQ-Nqol) into Persian by assessing the validity and reliability of the translated versions.</p> Methods <p>The English versions of the ICIQ-N and ICIQ-Nqol were translated into Persian using a forward–backward translation method. Content validity was assessed quantitatively using the Content Validity Index (CVI) and Content Validity Ratio (CVR) by ten urologists. Construct validity was evaluated using exploratory factor analysis (EFA) on data from 208 female patients with at least one lower urinary tract symptom. Internal consistency was determined using Cronbach’s alpha, and test–retest reliability was assessed over a 14-day interval using the intraclass correlation coefficient (ICC).</p> Result <p>The Persian translations demonstrated high content validity, with all items achieving acceptable CVI and CVR values. Exploratory factor analysis revealed a single dominant component for both questionnaires. Cronbach’s alpha for the ICIQ-N was 0.888 and for the ICIQ-Nqol was 0.986, indicating excellent internal consistency. Test–retest reliability was also high, with ICC values of 0.869 (95% CI 0.817–0.905) for the ICIQ-N and 0.974 (95% CI 0.968–0.979) for the ICIQ-Nqol.</p> Conclusion <p>The Persian ICIQ Nocturia and Nocturia Quality of Life were valid and efficiently adapted for use in various settings.</p>