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Introduction and Hypothesis <p>To investigate the potential correlation between the triglyceride-glucose (TyG) index and overactive bladder (OAB) symptoms within the female population.</p> Methods <p>This study used data from 7941 individuals obtained from the National Health and Nutrition Examination Survey (NHANES) 2005–2018 dataset. The following equation is used to calculate the TyG index: TyG = Ln [fasting triglycerides (mg/dL) * fasting glucose (mg/dL)/2]. The symptoms of OAB were based on individuals’ self-reported comprehensive score. Weighted logistic regression models, encompassing both univariable and multivariable analyses, were employed to evaluate the relationship between the TyG index and OAB in women.</p> Results <p>After conducting extensive modifications, the multivariable logistic regression model revealed a significant correlation between the TyG index and mild OAB among American female adults (OR 1.36, 95% CI 1.09–1.70, <i>P</i> = 0.006). Upon categorizing the TyG index into 4 grades (Q1–Q4), a positive increase in OR values corresponding to higher TyG index grades can be observed.</p> Conclusions <p>In this study, our findings reveal a significantly positive relationship between elevated TyG index values and an increased prevalence of mild OAB among female adults. These findings suggest that metabolic dysregulation may drive early-stage OAB, while severe OAB symptoms may be more dependent on non-metabolic pathological changes. Further investigation is warranted to elucidate the underlying mechanisms in female adults.</p>

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Association of the Triglyceride Glucose Index with Symptoms of Overactive Bladder in American Female Adults: A Cross-Sectional Study

  • 期刊论文

  • 发表日期：

    2025年4月29日

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  • Ke Huang,
  • Shan Yin,
  • Jianwei Cui,
  • Jiahao Wang,
  • Jia Wang,
  • Yunjin Bai

摘要

Introduction and Hypothesis

To investigate the potential correlation between the triglyceride-glucose (TyG) index and overactive bladder (OAB) symptoms within the female population.

Methods

This study used data from 7941 individuals obtained from the National Health and Nutrition Examination Survey (NHANES) 2005–2018 dataset. The following equation is used to calculate the TyG index: TyG = Ln [fasting triglycerides (mg/dL) * fasting glucose (mg/dL)/2]. The symptoms of OAB were based on individuals’ self-reported comprehensive score. Weighted logistic regression models, encompassing both univariable and multivariable analyses, were employed to evaluate the relationship between the TyG index and OAB in women.

Results

After conducting extensive modifications, the multivariable logistic regression model revealed a significant correlation between the TyG index and mild OAB among American female adults (OR 1.36, 95% CI 1.09–1.70, P = 0.006). Upon categorizing the TyG index into 4 grades (Q1–Q4), a positive increase in OR values corresponding to higher TyG index grades can be observed.

Conclusions

In this study, our findings reveal a significantly positive relationship between elevated TyG index values and an increased prevalence of mild OAB among female adults. These findings suggest that metabolic dysregulation may drive early-stage OAB, while severe OAB symptoms may be more dependent on non-metabolic pathological changes. Further investigation is warranted to elucidate the underlying mechanisms in female adults.