<p>Titanium-Tantalum (Ti-Ta) alloys are widely used in aerospace and biomedical engineering. This extensive application is attributed to their low density, high strength, excellent corrosion resistance and biocompatibility. However, the melting point difference between Ti and Ta is as high as 1328 ℃, and their density ratio is as high as 1:3.7. These characteristics significantly complicate the processing of Ti-Ta alloys. Impurities, pores and compositional segregation are introduced during processing. The microstructure and mechanical properties are highly dependent on the compositions of Ti-Ta alloys. The strength of Ti-Ta alloys is increased with higher Ta content. Furthermore, Ti-Ta alloys exhibit complex phase transformation mechanisms. Although significant progress has been made, challenges remain for Ti-Ta alloys. The melting route is prone to grain coarsening and segregation, and the powder metallurgy (PM) approach presents difficulties in alloying. In this paper, the research progress of preparation methods, microstructure and properties of Ti-Ta alloys are reviewed. The future research directions for Ti-Ta alloys is discussed.</p>