<p>The development of filler metals for producing biocompatible metal-ceramic brazed joints is a subject of great interest. The basis for such filler metals can be a titanium-zirconium system, additionally alloyed with copper and nickel to reduce the melting point. However, attention must also be paid to the pre-treatment of ceramics to improve the performance properties of the brazed joint. In this work, the ceramic surface was modified using a laser and titanium hydride powder. ZTA-Ti brazed joints were manufactured with various combinations of ceramic surface pre-treatments. It was found that the filler metal contact angle was 115° at 980&#xa0;°C on the ZTA ceramic surface treated with a laser. In the case of hydride application, the wetting angle dropped significantly to 15° at 980&#xa0;°C. A study of the microstructure showed that the brazed joint consists of α-(Ti, Zr) grains and an intermetallic Ti₂Cu compound. Corrosion tests in accordance with the ASTM F2129 standard demonstrated that brazed joints where titanium hydride treatment was not used for the ceramic surface did not meet the biocompatibility criteria due to corrosion of the intermetallic layer. The metal ion content in the Ringer’s Locke solution after testing exceeded the safe limit by several tens of times. Shear strength tests revealed that the fracture of the joints was brittle and occurred through the reaction layer and the ceramics itself. The strength ranged from 28.8 to 121&#xa0;MPa, depending on the treatment of the ceramic surface.</p>