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<p>Chronic wounds are prone to infections and can become severe and life-threatening. A quick recovery is only possible by the help of an external regeneration stimulus. Tissue regeneration of a skin patch depends on several factors including precise geometry, porosity, fluid intake, controlled degradation, biocompatible and bioactive materials, and a drug delivery system. The novel skin patches developed in this study via Direct Ink Write (DIW) 3D printing from a composite of polyvinylpyrrolidone (PVP) and sodium alginate (NaALG), with added zinc oxide nanoparticles (ZnO-nps) and mesoporous bioactive glass nanoparticles (MBGNs). The printed scaffolds have a uniform layer of 1 mm and average pore size of ⁓30µm, the swelling ratio of 87%, degradation of 62% and ⁓64 ppm Zn&#xa0;ion release in 14 days contribute to 14 mm antibacterial halo and cell viability of 109% after 7 days against human dermal fibroblasts. These indications make 3D printed patch an ideal candidate for skin regeneration.</p>

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Nano-technologically developed 3D-printed skin grafts: polyvinylpyrrolidone modified with zinc oxide and mesoporous bioactive glass nanoparticles for wound and skin regeneration application

  • 期刊论文

  • 发表日期：

    2025年9月29日

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  • Abdul Khaliq,
  • Awab Mughal,
  • Syed Muneeb Haider Gillani,
  • Mohamed Ramadan,
  • Imran Ali Chaudhry,
  • Muhammad Abdul Basit,
  • Rahila Batul,
  • Muhammad Tajammal Chughtai,
  • Muhammad Atiq Ur Rehman

摘要

Chronic wounds are prone to infections and can become severe and life-threatening. A quick recovery is only possible by the help of an external regeneration stimulus. Tissue regeneration of a skin patch depends on several factors including precise geometry, porosity, fluid intake, controlled degradation, biocompatible and bioactive materials, and a drug delivery system. The novel skin patches developed in this study via Direct Ink Write (DIW) 3D printing from a composite of polyvinylpyrrolidone (PVP) and sodium alginate (NaALG), with added zinc oxide nanoparticles (ZnO-nps) and mesoporous bioactive glass nanoparticles (MBGNs). The printed scaffolds have a uniform layer of 1 mm and average pore size of ⁓30µm, the swelling ratio of 87%, degradation of 62% and ⁓64 ppm Zn ion release in 14 days contribute to 14 mm antibacterial halo and cell viability of 109% after 7 days against human dermal fibroblasts. These indications make 3D printed patch an ideal candidate for skin regeneration.