<p>Rapid instantiation for the metamodels of product series is an effective way to realize design reuse. At present, the reuse unit in research mainly focuses on the level of single parts or small assemblies, and rarely on an overall product; therefore, it reduces the granularity of design reuse and depresses its application level. To solve this issue, the specific requirements are mapped to the space of design varieties with given parameters and constraints in product series, based on which the product metamodels are whereupon defined. The broad knowledge of design, process, and manufacture is embedded into metamodels, and the bridge between outer interfaces and inner implementation are established to form a connotated design closure. Through the mechanism of parameters driving and broad knowledge reasoning, the adaptive dimension/structure associating update of all components are achieved by parameters settings. Based on the CAD platforms, we have constructed the library for design models and knowledge expressions for the product series, which forms a design closure. Finally, the hierarchical and recursive parameterization scheme are applied according to the minimized external interfaces, and the comprehensive design result data together with specific derivatives can be obtained through simple settings. In this way, the design reuse is therefore realized, which greatly improves the efficiency of new product development, and the method is validated by two typical cases.</p>