<p>Refractory high-entropy alloys (RHEAs), as a new kind of alloy with many excellent properties, exhibit attractive application potential in harsh environments. Achieving better processing surface integrity plays an important role in accelerating their practical engineering applications. In this work, based on the material removal mode-driven design strategy, two RHEAs, W₁₀Ta₂₀Ti₃₄V₃₅C₁ and W₁₅(TaVZr)₈₅, were subjected to multi-pass wire electrical discharge machining (WEDM). The surface integrity was characterized and the effect of dendrite structure on WEDM removal mechanism was investigated. The results have shown that by multi-pass processing, the thickness of recast layer and volume fraction of deposited materials significantly decreased. Especially, the surface roughness of W₁₀Ta₂₀Ti₃₄V₃₅C₁ and W₁₅(TaVZr)₈₅ RHEAs was reduced by 67.38% and 81.80%, respectively, which is superior to the results in similar studies. The results confirmed the effectiveness of material removal mode-driven design strategy for improving surface integrity in multi-pass WEDM. Moreover, through theoretical analysis and experimental characterizations, it was shown that the interdendrites tend to be removed preferentially during WEDM of RHEAs with dendrite structure, and the underlying mechanisms were also elaborated. The present findings not only provide an effective strategy to improve the WEDMed surface integrity of RHEAs but also shed more light on the WEDM mechanisms of dendrite-structured RHEAs.</p>