<p>Carbon fiber-reinforced polymer (CFRP) and titanium alloy (Ti-6Al-4&#xa0;V) have excellent mechanical properties and have been extensively utilized in aviation, aerospace, and other fields. In the processing of CFRP/titanium alloy laminates, both are difficult to machine materials and have significant differences in physical and chemical properties. This results in issues such as tool wear and hole-making damage, thereby limiting its application in the main load-bearing components. Therefore, this study focuses on the cold air circulation integrated system of the presser foot as the research object and analyzes the interface gap between CFRP/titanium alloy laminates. The influence of the pressing force of the presser foot, the axial force during hole-making, and the support spacing of the clamping and fixing device on the interface gap of the laminated interface was obtained. A pressing force control system based on adaptive impedance control has been designed, and the stability of the control model was verified through simulation analysis. Subsequently, based on the improved genetic algorithm, the multi-objective optimization of the parameters of the laminated processing process was carried out. Concurrently, the analytic hierarchy process was employed to obtain the optimal solution for the processing parameters. Finally, the optimized parameters were experimentally verified through the inclined angle milling actuator, resulting in improved hole-making quality of the laminated material.</p>