<p>Form grinding is a high-efficiency machining technology for products as fir-tree blade slots. The excessive heat generated in the grinding contact zone is the key issue for form grinding. In this paper, a profile rotating heat pipe grinding wheel (PRHP-GW) was proposed to help dissipate the grinding heat; nanofluids were applied to enhance its thermal performance. The heat transfer performance of PRHP was experimentally studied. Diamond and Al₂O₃ nanofluids with different mass concentrations and nanoparticle sizes were applied and compared with deionized water. The experiments were performed under the conditions of different heat inputs, rotational speeds, and different filling ratios. At the same filling ratio, there was a significant reduction in thermal resistance with nanofluids as compared with deionized water. Under the heat input of 140 W, the thermal resistance decreases by about 17.6% and 19.3% for Al₂O₃ and diamond nanofluid, respectively. Diamond nanofluid with nanoparticle size of 20 nm, a mass concentration of 1.0 wt.%, and a filling ratio of 12% showed the best heat transfer performance with a thermal resistance of about 0.076 K/W. During the grinding of Ti-6Al-4V, PRHP-GW shows better heat transfer performance than the normal grinding wheel, and the maximum temperature decrease is about 29.9%. The comprehensive heat transfer performance of diamond nanofluids is the best, followed by Al₂O₃ nanofluid, and then deionized water. The results of this paper will provide new ideas for heat transfer enhancement of form grinding and possibly realize environmentally friendly grinding.</p>