<p>Traditional medical stents often encounter postoperative complications due to their extensive contact area with blood vessels and substantial weight. In contrast, the innovative design principles of tensegrity structures offer a fresh perspective for stent structural design. In this study, four different tensegrity stents are designed and optimized via multi-level optimization method. In the multi-level optimization process, the genetic algorithm is firstly used to optimize the tensegrity unit, and then optimize the combination process of the optimal tensegrity unit utilize same method; at the same time, the strut part is topology optimized based on the optimal unit, finally the optimal results are combined to obtain the final structure. By comparing the maximum von Mises stress of the tensegrity stent and the traditional stent under the same stress conditions, it is proved that the tensegrity stent exhibits significantly higher radial stiffness. In the last step, computational fluid dynamics is used to simulate the traditional structure and the optimal structure designed in this research. By comparing the shear stress and pressure of these two stents on the blood vessel wall, the superiority of the vascular stent designed based on the tensegrity structure is proved.</p>