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Background <p>Achieving optimal soft-tissue balance remains a&#xa0;key challenge in total knee arthroplasty (TKA), even with robotic assistance. The coronal plane alignment of the knee (CPAK) classification provides a&#xa0;structured description of constitutional alignment phenotypes, yet its relationship with intraoperative gap behavior has not been fully defined.</p> Methods <p>A&#xa0;prospective series of 285 patients undergoing robotic-assisted TKA with the CORI system was analyzed. Knees were categorized according to the CPAK classification and intraoperative medial and lateral gaps were automatically recorded in extension (0°) and flexion (90°). Gap configurations were defined as balanced, varus, or valgus. Associations between CPAK phenotypes and gap types were assessed using χ<sup>2</sup>and logistic regression analyses, with CPAK&#xa0;IV serving as the reference phenotype.</p> Results <p>The CPAK&#xa0;I and CPAK&#xa0;II phenotypes showed a&#xa0;significantly higher likelihood of varus gaps in both extension (odds ratio, OR 5.41 and 3.38, respectively) and flexion (OR 1.58 and 2.20, respectively), whereas CPAK&#xa0;VII was protective in extension (OR 0.23). Even valgus-aligned phenotypes demonstrated varus-dominant behavior in flexion. These findings indicate that gap behavior is strongly influenced by CPAK phenotype rather than solely by surgical alignment.</p> Conclusion <p>Intraoperative soft-tissue balance during TKA reflects the underlying CPAK phenotype. Integrating CPAK classification into robotic planning enables anticipation of gap tendencies and facilitates phenotype-driven balancing, bridging constitutional anatomy with functional alignment.</p> Graphic abstract <p></p>

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Coronal plane alignment of the knee (CPAK) phenotypes and their relationship with gap patterns in robotic-assisted total knee arthroplasty: a clinical trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月24日

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  • Filippo Migliorini,
  • Luise Schäfer,
  • Jens Schneider,
  • Andrea Maria Nobili,
  • Daniel Kämmer,
  • Nicola Maffulli,
  • Andreas Bell

摘要

Background

Achieving optimal soft-tissue balance remains a key challenge in total knee arthroplasty (TKA), even with robotic assistance. The coronal plane alignment of the knee (CPAK) classification provides a structured description of constitutional alignment phenotypes, yet its relationship with intraoperative gap behavior has not been fully defined.

Methods

A prospective series of 285 patients undergoing robotic-assisted TKA with the CORI system was analyzed. Knees were categorized according to the CPAK classification and intraoperative medial and lateral gaps were automatically recorded in extension (0°) and flexion (90°). Gap configurations were defined as balanced, varus, or valgus. Associations between CPAK phenotypes and gap types were assessed using χ2and logistic regression analyses, with CPAK IV serving as the reference phenotype.

Results

The CPAK I and CPAK II phenotypes showed a significantly higher likelihood of varus gaps in both extension (odds ratio, OR 5.41 and 3.38, respectively) and flexion (OR 1.58 and 2.20, respectively), whereas CPAK VII was protective in extension (OR 0.23). Even valgus-aligned phenotypes demonstrated varus-dominant behavior in flexion. These findings indicate that gap behavior is strongly influenced by CPAK phenotype rather than solely by surgical alignment.

Conclusion

Intraoperative soft-tissue balance during TKA reflects the underlying CPAK phenotype. Integrating CPAK classification into robotic planning enables anticipation of gap tendencies and facilitates phenotype-driven balancing, bridging constitutional anatomy with functional alignment.

Graphic abstract