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<p>Antibody–drug conjugates (ADCs) are therapeutics which have become a&#xa0;relevant option in the treatment of metastatic breast cancer (mBC) in every subtype. The combination of targeted therapy with a&#xa0;cytotoxic effect demonstrated remarkable benefits compared to conventional chemotherapy in advanced therapy lines. In addition, ADCs generally show favorable toxicity profiles with improved quality of life. In hormone receptor (HR)-positive human epidermal growth factor receptor 2 (HER2)-negative mBC, ADCs should be used after exhausting endocrine-based therapy. While sacituzumab govitecan can be used in all patients with HR+ HER2 mBC, the use of trastuzumab deruxtecan is limited to those with low HER2 expression. For the triple-negative mBC, sacituzumab govitecan is recommended after two lines of systemic therapy. In HER2-positive mBC, the combination of classic chemotherapy and HER2-directed antibody therapy with trastuzumab and pertuzumab is standard in first-line setting. In second line, trastuzumab deruxtecan is recommended in the guidelines.</p>

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ADCs beim metastasierten Mammakarzinom

  • 期刊论文

  • 发表日期：

    2025年4月4日

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  • Katharina Kaschner,
  • Achim Rody,
  • Maggie Banys-Paluchowski

摘要

Antibody–drug conjugates (ADCs) are therapeutics which have become a relevant option in the treatment of metastatic breast cancer (mBC) in every subtype. The combination of targeted therapy with a cytotoxic effect demonstrated remarkable benefits compared to conventional chemotherapy in advanced therapy lines. In addition, ADCs generally show favorable toxicity profiles with improved quality of life. In hormone receptor (HR)-positive human epidermal growth factor receptor 2 (HER2)-negative mBC, ADCs should be used after exhausting endocrine-based therapy. While sacituzumab govitecan can be used in all patients with HR+ HER2 mBC, the use of trastuzumab deruxtecan is limited to those with low HER2 expression. For the triple-negative mBC, sacituzumab govitecan is recommended after two lines of systemic therapy. In HER2-positive mBC, the combination of classic chemotherapy and HER2-directed antibody therapy with trastuzumab and pertuzumab is standard in first-line setting. In second line, trastuzumab deruxtecan is recommended in the guidelines.