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<p>Breast cancer is the most common cancer in women, with 40% of cases in Germany diagnosed after the age of&#xa0;70. Despite the increasing focus on older oncological patients, they remain underrepresented in clinical trials. Functional age and frailty, not chronological age, should guide treatment decisions. A&#xa0;comprehensive geriatric assessment (cGA) or a&#xa0;“prescreening” before a&#xa0;cGA should be standard before treatment, but no later than the age of&#xa0;75. To estimate overall survival, calculators such as ePrognosis are used. Additionally, chemotherapy toxicity calculators for older oncology patients (e.g., CARG/CRASH) can be employed in treatment planning. In the context of treatment decisions for older patients, both overtreatment and undertreatment of fit older patients should be avoided. The goal is to provide personalized care that balances treatment benefits against toxicity risks and impact on quality of life. This approach ensures that older breast cancer patients receive optimal, individualized care considering their health status and preferences.</p>

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Die ältere Patientin im Fokus der Senologie

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月11日

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  • Valerie Catherine Linz,
  • Marcus Schmidt,
  • Annette Hasenburg

摘要

Breast cancer is the most common cancer in women, with 40% of cases in Germany diagnosed after the age of 70. Despite the increasing focus on older oncological patients, they remain underrepresented in clinical trials. Functional age and frailty, not chronological age, should guide treatment decisions. A comprehensive geriatric assessment (cGA) or a “prescreening” before a cGA should be standard before treatment, but no later than the age of 75. To estimate overall survival, calculators such as ePrognosis are used. Additionally, chemotherapy toxicity calculators for older oncology patients (e.g., CARG/CRASH) can be employed in treatment planning. In the context of treatment decisions for older patients, both overtreatment and undertreatment of fit older patients should be avoided. The goal is to provide personalized care that balances treatment benefits against toxicity risks and impact on quality of life. This approach ensures that older breast cancer patients receive optimal, individualized care considering their health status and preferences.