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Objectives <p>This study aimed to investigate the association between induced abortion (IA) and bipolar disorder and major depression (BDMD), and explore the dose-response relationship between them.</p> Methods <p>We used cross-sectional data including 13,200 females from the UK Biobank. Self-reported IA was categorized into two groups: Non-IA(no history of induced abortion) and IA(≥ 1 induced abortions). Covariates adjustment, propensity score matching (PSM), and inverse probability of treatment weighting (IPTW) were used to balance the baseline characteristics of the two groups. A three-knot restricted cubic spline regression model was used to examine the dose-response relationship between the number of IAs and BDMD.</p> Results <p>IPTW multivariable logistic regression and PSM multivariable logistic regression analyses indicated that there was a significant association between IA and BDMD, with odds ratios (ORs) of 1.25 (95% confidence interval [CI]: 1.19 to 1.32) and 1.25 (95% CI: 1.10 to 1.41), respectively. There was a significant positive association between the number of IAs and BDMD. Specifically, for individuals reporting 1–2 IAs compared to none, the ORs were 1.25 (95% CI: 1.18 to 1.32) and 1.23 (95% CI: 1.09 to 1.40), and for those with ≥ 3 IAs, the ORs were 1.32 (95% CI: 1.10 to 1.59) and 1.55 (95% CI: 1.13 to 2.34). The three-knot restricted cubic spline regression model revealed a nonlinear relationship between the number of IAs and BDMD.</p> Conclusion <p>There is a significant association between IA and BDMD. Therefore, mental health care for women who reported experiencing induced abortion is crucial.</p>

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Association of induced abortion with bipolar disorder and major depression from the UK Biobank: a propensity score matching and weighting analysis

  • 期刊论文

  • 发表日期：

    2026年7月8日

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  • Hao Sun,
  • Can Liu,
  • Yuying Wang,
  • Huan Liu,
  • Yanjie Chen,
  • Ziyan Chu,
  • Hongpeng Sun,
  • Liping Tan,
  • Zaixiang Tang

摘要

Objectives

This study aimed to investigate the association between induced abortion (IA) and bipolar disorder and major depression (BDMD), and explore the dose-response relationship between them.

Methods

We used cross-sectional data including 13,200 females from the UK Biobank. Self-reported IA was categorized into two groups: Non-IA(no history of induced abortion) and IA(≥ 1 induced abortions). Covariates adjustment, propensity score matching (PSM), and inverse probability of treatment weighting (IPTW) were used to balance the baseline characteristics of the two groups. A three-knot restricted cubic spline regression model was used to examine the dose-response relationship between the number of IAs and BDMD.

Results

IPTW multivariable logistic regression and PSM multivariable logistic regression analyses indicated that there was a significant association between IA and BDMD, with odds ratios (ORs) of 1.25 (95% confidence interval [CI]: 1.19 to 1.32) and 1.25 (95% CI: 1.10 to 1.41), respectively. There was a significant positive association between the number of IAs and BDMD. Specifically, for individuals reporting 1–2 IAs compared to none, the ORs were 1.25 (95% CI: 1.18 to 1.32) and 1.23 (95% CI: 1.09 to 1.40), and for those with ≥ 3 IAs, the ORs were 1.32 (95% CI: 1.10 to 1.59) and 1.55 (95% CI: 1.13 to 2.34). The three-knot restricted cubic spline regression model revealed a nonlinear relationship between the number of IAs and BDMD.

Conclusion

There is a significant association between IA and BDMD. Therefore, mental health care for women who reported experiencing induced abortion is crucial.