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<p>Pancreatic islets of Langerhans are central to the pathogenesis of all major forms of diabetes. The ability to study human islets ex vivo has advanced our understanding of diabetes and aided in the development of novel therapeutics. However, for decades, very few laboratories had access to this critical resource and experiments on human islets were typically underpowered. More recently, multiple consortia around the world have started to enable islet biology at scale, enriching our understanding of the intra-individual variability of islet function and disease mechanisms. This article reviews and compares existing large-scale human islet tissue and data resources, offering suggestions for their improvement and for developing new resources.</p> Graphical Abstract <p></p>

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From pancreas and islet resources to diabetes insights

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月1日

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  • Sing-Young Chen,
  • Christiana Lekka,
  • Jonas Lemvig,
  • Xiaoyan Yi,
  • Miriam Cnop,
  • Piero Marchetti,
  • Lorella Marselli,
  • Jianguo Xia,
  • Jesper G. S. Madsen,
  • Teresa Rodriguez-Calvo,
  • Sarah J. Richardson,
  • James D. Johnson,
  • Patrick E. MacDonald

摘要

Pancreatic islets of Langerhans are central to the pathogenesis of all major forms of diabetes. The ability to study human islets ex vivo has advanced our understanding of diabetes and aided in the development of novel therapeutics. However, for decades, very few laboratories had access to this critical resource and experiments on human islets were typically underpowered. More recently, multiple consortia around the world have started to enable islet biology at scale, enriching our understanding of the intra-individual variability of islet function and disease mechanisms. This article reviews and compares existing large-scale human islet tissue and data resources, offering suggestions for their improvement and for developing new resources.

Graphical Abstract