Scholarlink

Aims/hypothesis <p>The relationship between the progression of arterial stiffness and the risk of chronic kidney disease (CKD) remains unclear. This study aimed to evaluate the time-dependent association between the progression of arterial stiffness and the risk of CKD.</p> Methods <p>We followed 10,567 individuals in the Kailuan Study, who were free of CKD and CVD at baseline. Arterial stiffness was repeatedly measured by brachial–ankle pulse wave velocity (baPWV) from baseline to the subsequent follow-ups. Time-dependent Cox models were used to estimate the association between progression of arterial stiffness (△baPWV/years) and incident CKD, defined as an eGFR below 60 ml/min per 1.73 m<sup>2</sup> and/or the presence of albuminuria.</p> Results <p>During a mean follow-up of 5.32 years, 1108 participants developed CKD. Lower quintiles in baPWV at baseline and the progression of baPWV over time were associated with a lower risk of CKD in a dose-dependent manner (<i>p</i>-trend &lt;0.001). Compared with participants with the greatest deterioration in arterial stiffness (quintile 5), those with the greatest improvement in arterial stiffness (quintile 1) had a 45% (95% CI 34, 55) lower risk of CKD. Each SD increment in the progression of baPWV was associated with a 19% higher risk of CKD. Additionally, compared with participants who consistently had high baPWV (≥1400 cm/s), participants who maintained low baPWV (&lt;1400 cm/s) or improved from high to low baPWV over time had a 46% (95% CI 33, 57) or 32% (95% CI 12, 48) lower risk of incident CKD, respectively. Adding progression of arterial stiffness to the CKD risk model modestly improved discrimination (optimism-adjusted <i>C</i> statistic from 0.690 to 0.709, <i>p</i>&lt;0.001).</p> Conclusions/interpretation <p>In this cohort study, improvement in arterial stiffness, as indicated by a consistently low or decreased baPWV, might be associated with a lower risk of CKD. These findings underscore the potential importance of coordinated actions targeting cardiovascular health to improve kidney health in the general population.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Time-dependent association between progression of arterial stiffness and risk of incident chronic kidney disease: a cohort study in China

  • 期刊论文

  • 发表日期：

    2025年11月22日

查看全文
  • Jing-li Gao,
  • Hua Deng,
  • Guo-Dong Wang,
  • Hui-ling Deng,
  • Dong-Yi Feng,
  • Shou-ling Wu,
  • Shuo-hua Chen,
  • Yan-Feng Zhou

摘要

Aims/hypothesis

The relationship between the progression of arterial stiffness and the risk of chronic kidney disease (CKD) remains unclear. This study aimed to evaluate the time-dependent association between the progression of arterial stiffness and the risk of CKD.

Methods

We followed 10,567 individuals in the Kailuan Study, who were free of CKD and CVD at baseline. Arterial stiffness was repeatedly measured by brachial–ankle pulse wave velocity (baPWV) from baseline to the subsequent follow-ups. Time-dependent Cox models were used to estimate the association between progression of arterial stiffness (△baPWV/years) and incident CKD, defined as an eGFR below 60 ml/min per 1.73 m2 and/or the presence of albuminuria.

Results

During a mean follow-up of 5.32 years, 1108 participants developed CKD. Lower quintiles in baPWV at baseline and the progression of baPWV over time were associated with a lower risk of CKD in a dose-dependent manner (p-trend <0.001). Compared with participants with the greatest deterioration in arterial stiffness (quintile 5), those with the greatest improvement in arterial stiffness (quintile 1) had a 45% (95% CI 34, 55) lower risk of CKD. Each SD increment in the progression of baPWV was associated with a 19% higher risk of CKD. Additionally, compared with participants who consistently had high baPWV (≥1400 cm/s), participants who maintained low baPWV (<1400 cm/s) or improved from high to low baPWV over time had a 46% (95% CI 33, 57) or 32% (95% CI 12, 48) lower risk of incident CKD, respectively. Adding progression of arterial stiffness to the CKD risk model modestly improved discrimination (optimism-adjusted C statistic from 0.690 to 0.709, p<0.001).

Conclusions/interpretation

In this cohort study, improvement in arterial stiffness, as indicated by a consistently low or decreased baPWV, might be associated with a lower risk of CKD. These findings underscore the potential importance of coordinated actions targeting cardiovascular health to improve kidney health in the general population.

Graphical Abstract