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Background <p>Immunotherapies have become an integral part of modern oncology. Despite their therapeutic success, they are associated with cardiotoxic side effects that require early detection. Cardiac magnetic resonance imaging (CMR), as a&#xa0;noninvasive modality, enables precise tissue characterization of immune-mediated myocardial injury.</p> Objectives <p>To present cardiotoxic effects of immunotherapies and the role of CMR in diagnosis and risk stratification.</p> Materials and methods <p>Current scientific literature and clinical guidelines were reviewed regarding the incidence, pathophysiology, and imaging-based diagnosis of cardiotoxic effects related to immunotherapies.</p> Results <p>Myocarditis associated with immune checkpoint inhibitors is rare but linked to high mortality. Chimeric antigen receptor (CAR)-T-related cardiotoxicity often occurs in the context of cytokine release syndrome and can be assessed by CMR with respect to both functional and structural myocardial changes.</p> Conclusion <p>CMR plays a&#xa0;central role in the noninvasive diagnosis of immunotherapy-related cardiotoxicity and is essential for clinical decision-making and risk stratification.</p>

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Kardiale Nebenwirkungen von Immuntherapien

  • 期刊论文

  • 发表日期：

    2025年12月16日

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  • Taraneh Aziz-Safaie,
  • Lucia D. Beissel,
  • Annemarie Proff,
  • Julian A. Luetkens,
  • Alexander Isaak

摘要

Background

Immunotherapies have become an integral part of modern oncology. Despite their therapeutic success, they are associated with cardiotoxic side effects that require early detection. Cardiac magnetic resonance imaging (CMR), as a noninvasive modality, enables precise tissue characterization of immune-mediated myocardial injury.

Objectives

To present cardiotoxic effects of immunotherapies and the role of CMR in diagnosis and risk stratification.

Materials and methods

Current scientific literature and clinical guidelines were reviewed regarding the incidence, pathophysiology, and imaging-based diagnosis of cardiotoxic effects related to immunotherapies.

Results

Myocarditis associated with immune checkpoint inhibitors is rare but linked to high mortality. Chimeric antigen receptor (CAR)-T-related cardiotoxicity often occurs in the context of cytokine release syndrome and can be assessed by CMR with respect to both functional and structural myocardial changes.

Conclusion

CMR plays a central role in the noninvasive diagnosis of immunotherapy-related cardiotoxicity and is essential for clinical decision-making and risk stratification.