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Clinical/methodological issue <p>Imaging plays a&#xa0;central role in the staging and biopsy-based diagnosis of malignant lymphomas. The diagnostic approach using core needle biopsy requires an interdisciplinary strategy that integrates clinical, histopathological and molecular characteristics of non-Hodgkin′s lymphomas (NHL).</p> Standard radiological methods <p>Ultrasound and/or computed tomography (CT)-guided biopsy.</p> Methodological innovations <p>The current WHO classification defines over 40&#xa0;non-Hodgkin′s lymphoma entities, taking the genomic heterogeneity into account.</p> Performance/achievements <p>This review focuses on non-Hodgkin′s lymphomas with imaging-based diagnostic relevance, including indolent and aggressive B‑NHL as well as systemic T/NK-NHL. It also discusses technical aspects of core needle biopsy and treatment-related effects that can impact the biopsy quality. Special attention is paid to the role of imaging and biopsy techniques in detecting high-grade transformation of indolent B‑NHL, which is associated with rapid progression and diagnostic challenges.</p> Practical recommendations <p>Ultrasound-guided and CT-guided core needle biopsies are well-established standard procedures with a high sensitivity. Close interdisciplinary collaboration between radiology and pathology, along with structured communication of clinical information are essential to ensure high diagnostic accuracy.</p>

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Maligne Non-Hodgkin-Lymphome

  • 期刊论文

  • 发表日期：

    2025年5月5日

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  • M. Andrulis

摘要

Clinical/methodological issue

Imaging plays a central role in the staging and biopsy-based diagnosis of malignant lymphomas. The diagnostic approach using core needle biopsy requires an interdisciplinary strategy that integrates clinical, histopathological and molecular characteristics of non-Hodgkin′s lymphomas (NHL).

Standard radiological methods

Ultrasound and/or computed tomography (CT)-guided biopsy.

Methodological innovations

The current WHO classification defines over 40 non-Hodgkin′s lymphoma entities, taking the genomic heterogeneity into account.

Performance/achievements

This review focuses on non-Hodgkin′s lymphomas with imaging-based diagnostic relevance, including indolent and aggressive B‑NHL as well as systemic T/NK-NHL. It also discusses technical aspects of core needle biopsy and treatment-related effects that can impact the biopsy quality. Special attention is paid to the role of imaging and biopsy techniques in detecting high-grade transformation of indolent B‑NHL, which is associated with rapid progression and diagnostic challenges.

Practical recommendations

Ultrasound-guided and CT-guided core needle biopsies are well-established standard procedures with a high sensitivity. Close interdisciplinary collaboration between radiology and pathology, along with structured communication of clinical information are essential to ensure high diagnostic accuracy.