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Background <p>On 15 October 2025, the revised S3 guideline on schizophrenia (living) was published and transferred to the MAGICapp evidence ecosystem and will be updated annually in the future.</p> Objective <p>This narrative review summarizes essential innovations and explains their development.</p> Material and methods <p>New and revised recommendations and MAGICapp background information were extracted and summarized.</p> Results and conclusion <p>The guideline is now fully integrated into MAGICapp and annually updated. Key changes include a&#xa0;downgrading of the recommendation for antipsychotic monotherapy, a&#xa0;substantial expansion of guidance on adverse effect monitoring and management and a&#xa0;strengthened emphasis on evidence-based psychotherapeutic interventions, such as metacognitive training and systemic therapy. Additionally, 4 new recommendations (digital/technology-assisted interventions, mindfulness-based procedures, acceptance and commitment therapy [ACT], trauma-focussed therapy for post-traumatic stress disorder [PTSD]) were implemented and 12 were removed. All chapters were comprehensively revised.</p>

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Die neue S3-Leitlinie Schizophrenie (living) 2025

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月2日

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  • Theresa Halms,
  • Wolfgang Gaebel,
  • Stefan Leucht,
  • Peter Falkai,
  • Tania Lincoln,
  • Andreas Bechdolf,
  • Christoph U. Correll,
  • Stefanie J. Schmidt,
  • Martin Lambert,
  • Thomas Wobrock,
  • Alkomiet Hasan

摘要

Background

On 15 October 2025, the revised S3 guideline on schizophrenia (living) was published and transferred to the MAGICapp evidence ecosystem and will be updated annually in the future.

Objective

This narrative review summarizes essential innovations and explains their development.

Material and methods

New and revised recommendations and MAGICapp background information were extracted and summarized.

Results and conclusion

The guideline is now fully integrated into MAGICapp and annually updated. Key changes include a downgrading of the recommendation for antipsychotic monotherapy, a substantial expansion of guidance on adverse effect monitoring and management and a strengthened emphasis on evidence-based psychotherapeutic interventions, such as metacognitive training and systemic therapy. Additionally, 4 new recommendations (digital/technology-assisted interventions, mindfulness-based procedures, acceptance and commitment therapy [ACT], trauma-focussed therapy for post-traumatic stress disorder [PTSD]) were implemented and 12 were removed. All chapters were comprehensively revised.