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<p>Head and neck squamous carcinoma (HNSCC) is one of the most common malignant tumors in the upper gastrointestinal tract. Inherited genes are non-modifiable risk factors for HNSCC. This study aims to determine the association between <i>LINC-PINT</i> polymorphism and the risk of HNSCC risk in a Chinese Han population.&#xa0;Genomic DNA was extracted from the whole blood samples of 524 HNSCC patients and 517 healthy controls. The associations of <i>LINC-PINT</i> polymorphisms and HNSCC susceptibility were evaluated through logistic regression analysis.&#xa0;Our study showed that rs157916, rs16873842, and rs7781295 were related to an increased susceptibility to HNSCC. Stratification analyses demonstrated that rs157916 and rs7781295 were associated with an increased risk of HNSCC in age ≤ 46&#xa0;years, men, and thyroid SCC. Rs16873842 and rs7801029 showed an enhanced risk of HNSCC in men. Additionally, rs16873842 and rs7781295 may increase the risk of Nasopharyngeal SCC. Moreover, the combination of rs7801029 and rs7781295 could serve as a predictive model for HNSCC.&#xa0;This study suggests that <i>LINC-PINT</i> polymorphisms may be correlated with an increased risk of HNSCC.</p>

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The Impact of LINC-PINT polymorphisms on HNSCC risk in a Chinese han population

  • 期刊论文

  • 发表日期：

    2025年9月16日

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  • Lingyu Kong,
  • Wenjing Wang,
  • Hang Meng,
  • Mengnan Hou,
  • Shan Wang,
  • Wanli Ren,
  • Hao Dai,
  • Bin Li,
  • Tianbo Jin

摘要

Head and neck squamous carcinoma (HNSCC) is one of the most common malignant tumors in the upper gastrointestinal tract. Inherited genes are non-modifiable risk factors for HNSCC. This study aims to determine the association between LINC-PINT polymorphism and the risk of HNSCC risk in a Chinese Han population. Genomic DNA was extracted from the whole blood samples of 524 HNSCC patients and 517 healthy controls. The associations of LINC-PINT polymorphisms and HNSCC susceptibility were evaluated through logistic regression analysis. Our study showed that rs157916, rs16873842, and rs7781295 were related to an increased susceptibility to HNSCC. Stratification analyses demonstrated that rs157916 and rs7781295 were associated with an increased risk of HNSCC in age ≤ 46 years, men, and thyroid SCC. Rs16873842 and rs7801029 showed an enhanced risk of HNSCC in men. Additionally, rs16873842 and rs7781295 may increase the risk of Nasopharyngeal SCC. Moreover, the combination of rs7801029 and rs7781295 could serve as a predictive model for HNSCC. This study suggests that LINC-PINT polymorphisms may be correlated with an increased risk of HNSCC.