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<p>Cotrimoxazole is a&#xa0;combination antibiotic composed of the two active substances trimethoprim and sulfamethoxazole (TMP-SMX). TMP-SMX is known to affect renal function parameters. It can cause true acute kidney injury but may also mimic acute kidney injury by inhibiting the renal secretion of creatinine. The present case demonstrates a&#xa0;significant increase in creatinine and urea levels, along with a&#xa0;reduced glomerular filtration rate, while cystatin C&#xa0;levels remained unchanged, representing an extent of alteration not previously reported in this form.</p>

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Veränderungen der Nierenfunktionsparameter nach Cotrimoxazoltherapie

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月23日

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  • John Michael Hoppe,
  • Martin Klaus,
  • Matthias Auer,
  • Markus Wörnle

摘要

Cotrimoxazole is a combination antibiotic composed of the two active substances trimethoprim and sulfamethoxazole (TMP-SMX). TMP-SMX is known to affect renal function parameters. It can cause true acute kidney injury but may also mimic acute kidney injury by inhibiting the renal secretion of creatinine. The present case demonstrates a significant increase in creatinine and urea levels, along with a reduced glomerular filtration rate, while cystatin C levels remained unchanged, representing an extent of alteration not previously reported in this form.