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Background <p>Patients with hypertension, diabetes mellitus (DM) and/or cardiovascular disease (CVD) have a&#xa0;higher risk of developing chronic kidney disease (CKD) and should therefore be closely monitored. Early diagnosis and guideline-directed disease management can reduce the risk of kidney failure and cardiorenal complications.</p> Objectives <p>The aim of this retrospective cross-sectional study was to gain a&#xa0;better understanding of the prevalence, diagnosis, and guideline-directed treatment of CKD in patients at risk for CKD in German general practitioner (GP) practices.</p> Materials and methods <p>A&#xa0;total of 1244 GPs provided fully anonymized electronic data sets for the analysis (study period 06/2020–06/2023). According to the screening recommendations of Kidney Disease: Improving Global Outcomes (KDIGO), adults with hypertension and/or DM and/or CVD with a&#xa0;documented observation period of at least 1&#xa0;year were included in the study.</p> Results <p>The prevalence of CKD was 18.8% (<i>n</i> = 24,179), of which 16.5% of at-risk patients (<i>n</i> = 3986) had a&#xa0;documented diagnosis of CKD according to the International Statistical Classification of Diseases and Related Health Problems (ICD-10). Thus, 83.5% (<i>n</i> = 20.193) of patients at risk remained undiagnosed. Within 6&#xa0;months of diagnosis, 9.7% (<i>n</i> = 1740) of ICD-10-diagnosed CKD patients were treated with a&#xa0;renin-angiotensin system inhibitor (RASi) in combination with a&#xa0;sodium-glucose cotransporter‑2 inhibitor (SGLT2i).</p> Conclusion <p>The results highlight substantial gaps in early diagnosis and treatment of CKD in Germany. There is an urgent need for greater awareness among GPs of this under-recognized disease.</p>

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InspeCKD – Analyse zur Prävalenz, Diagnose und Therapie der chronischen Nierenerkrankung

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月4日

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  • Christoph Wanner,
  • Elke Schaeffner,
  • Thomas Frese,
  • Ulrich Opfermann,
  • Frank Radowsky,
  • Philipp Stahl,
  • Fabian Burckhardt,
  • Felix Scherg,
  • Christoph Weber,
  • Frederik Mader

摘要

Background

Patients with hypertension, diabetes mellitus (DM) and/or cardiovascular disease (CVD) have a higher risk of developing chronic kidney disease (CKD) and should therefore be closely monitored. Early diagnosis and guideline-directed disease management can reduce the risk of kidney failure and cardiorenal complications.

Objectives

The aim of this retrospective cross-sectional study was to gain a better understanding of the prevalence, diagnosis, and guideline-directed treatment of CKD in patients at risk for CKD in German general practitioner (GP) practices.

Materials and methods

A total of 1244 GPs provided fully anonymized electronic data sets for the analysis (study period 06/2020–06/2023). According to the screening recommendations of Kidney Disease: Improving Global Outcomes (KDIGO), adults with hypertension and/or DM and/or CVD with a documented observation period of at least 1 year were included in the study.

Results

The prevalence of CKD was 18.8% (n = 24,179), of which 16.5% of at-risk patients (n = 3986) had a documented diagnosis of CKD according to the International Statistical Classification of Diseases and Related Health Problems (ICD-10). Thus, 83.5% (n = 20.193) of patients at risk remained undiagnosed. Within 6 months of diagnosis, 9.7% (n = 1740) of ICD-10-diagnosed CKD patients were treated with a renin-angiotensin system inhibitor (RASi) in combination with a sodium-glucose cotransporter‑2 inhibitor (SGLT2i).

Conclusion

The results highlight substantial gaps in early diagnosis and treatment of CKD in Germany. There is an urgent need for greater awareness among GPs of this under-recognized disease.