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<p>More than 70&#xa0;years after the first successful organ transplant between identical twins, transplantation medicine still faces significant challenges today: How can the large number of people waiting for a&#xa0;new kidney, liver, lung, or heart receive a&#xa0;suitable organ more quickly? How can survival on the waiting list be extended? How can long-term graft survival with high quality of life be ensured after transplantation? The various disciplines of transplantation medicine are working daily to address these challenges. The goal of this overview article is to provide practicing physicians with an overview of the current state and medium-term perspectives of transplantation medicine. For this purpose, an interdisciplinary team of transplantation experts from the largest transplant center in Germany has come together to summarize the current innovations and future perspectives of transplantation medicine in a&#xa0;compact and organ-overarching format. Specifically, new bridging strategies to improve survival on the waiting list will be discussed and possibilities for expanding the donor pool explored. Future perspectives on conditioning explanted donor organs using machine perfusion strategies will also be addressed and current developments in personalized post-transplant care summarized.</p>

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Innovationen in der Transplantationsmedizin

  • 期刊论文

  • 发表日期：

    2025年7月23日

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  • Kai M. Schmidt-Ott,
  • Arjang Ruhparwar,
  • Fabio Ius,
  • Bastian Schmack,
  • Moritz Schmelzle,
  • Heiner Wedemeyer

摘要

More than 70 years after the first successful organ transplant between identical twins, transplantation medicine still faces significant challenges today: How can the large number of people waiting for a new kidney, liver, lung, or heart receive a suitable organ more quickly? How can survival on the waiting list be extended? How can long-term graft survival with high quality of life be ensured after transplantation? The various disciplines of transplantation medicine are working daily to address these challenges. The goal of this overview article is to provide practicing physicians with an overview of the current state and medium-term perspectives of transplantation medicine. For this purpose, an interdisciplinary team of transplantation experts from the largest transplant center in Germany has come together to summarize the current innovations and future perspectives of transplantation medicine in a compact and organ-overarching format. Specifically, new bridging strategies to improve survival on the waiting list will be discussed and possibilities for expanding the donor pool explored. Future perspectives on conditioning explanted donor organs using machine perfusion strategies will also be addressed and current developments in personalized post-transplant care summarized.