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<p>At 1.5&#xa0;years after the diagnosis of glutamate decarboxylase(GAD)-associated encephalitis (highly positive GAD antibodies in cerebrospinal fluid and serum) in a&#xa0;72-year-old patient, hyperglycemia above 40 mmol/l was the cause of progressive neurological symptoms. GAD is an important enzyme in the central nervous system and pancreatic β‑cells that convert L‑glutamate into γ‑aminobutyric acid (GABA). High GAD antibodies are associated with autoimmune diseases such as encephalitis and diabetes mellitus type&#xa0;1, requiring interdisciplinary diagnostics and therapy.</p>

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Gleiche Antikörper, neue Fragen – interdisziplinäre Diagnostik bei einer 72-jährigen Patientin mit Enzephalitis

  • 期刊论文

  • 发表日期：

    2025年6月16日

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  • Christiane Kellner,
  • Mihai Ceanga,
  • Jakob Leicht,
  • Christian Kühnel,
  • Mina Piramoon,
  • Christof Kloos,
  • Nicolle Müller,
  • Gunter Wolf

摘要

At 1.5 years after the diagnosis of glutamate decarboxylase(GAD)-associated encephalitis (highly positive GAD antibodies in cerebrospinal fluid and serum) in a 72-year-old patient, hyperglycemia above 40 mmol/l was the cause of progressive neurological symptoms. GAD is an important enzyme in the central nervous system and pancreatic β‑cells that convert L‑glutamate into γ‑aminobutyric acid (GABA). High GAD antibodies are associated with autoimmune diseases such as encephalitis and diabetes mellitus type 1, requiring interdisciplinary diagnostics and therapy.