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<p>Staphylococcal scalded skin syndrome (SSSS) is a&#xa0;rare, toxin-mediated skin disorder of childhood, caused by the exfoliative toxins ETA and ETB released by <i>Staphylococcus aureus</i>. We report on a&#xa0;4-year-old boy who presented with a&#xa0;5-day history of painful, progressive blistering of the face, trunk and anogenital region. Clinical examination revealed widespread erythema with coarse lamellar desquamation, flaccid blisters and a&#xa0;positive Nikolsky sign; the mucous membranes were spared, an important feature distinguishing SSSS from toxic epidermal necrolysis and Stevens–Johnson syndrome. Under parenteral flucloxacillin and clindamycin combined with antiseptic wound care and supportive treatment, the skin healed completely within 1&#xa0;week. Because delayed treatment can substantially increase mortality, prompt recognition of SSSS and the immediate initiation of empirical antibiotic therapy are decisive for prognosis.</p>

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„Staphylococcal scalded skin syndrome“: ein kinderdermatologischer Notfall

  • 期刊论文

  • 发表日期：

    2026年7月9日

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  • Mohammed Mitwalli,
  • Kathrin Giehl,
  • Laura Engels,
  • Lars E. French

摘要

Staphylococcal scalded skin syndrome (SSSS) is a rare, toxin-mediated skin disorder of childhood, caused by the exfoliative toxins ETA and ETB released by Staphylococcus aureus. We report on a 4-year-old boy who presented with a 5-day history of painful, progressive blistering of the face, trunk and anogenital region. Clinical examination revealed widespread erythema with coarse lamellar desquamation, flaccid blisters and a positive Nikolsky sign; the mucous membranes were spared, an important feature distinguishing SSSS from toxic epidermal necrolysis and Stevens–Johnson syndrome. Under parenteral flucloxacillin and clindamycin combined with antiseptic wound care and supportive treatment, the skin healed completely within 1 week. Because delayed treatment can substantially increase mortality, prompt recognition of SSSS and the immediate initiation of empirical antibiotic therapy are decisive for prognosis.