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<p>Allergological emergencies represent a&#xa0;particular challenge in clinical practice, as they require rapid identification and appropriate treatment to prevent serious complications and life-threatening courses. These emergencies primarily include life-threatening systemic hypersensitivity reactions—anaphylaxis—which can manifest on the skin as generalized urticaria and the development of angioedema, as well as severe cutaneous adverse drug reactions (SCADR). Among these, toxic epidermal necrolysis (TEN) represents the most severe one with a&#xa0;mortality rate of up to 30%. In the following article, we will discuss the current state-of-the-art diagnostics and treatment strategies for these dermatological emergencies and highlight new and promising therapeutic approaches.</p>

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Übersicht zur Klinik, Diagnostik und Therapie von akuten allergologischen Krankheitsbildern

  • 期刊论文

  • 发表日期：

    2025年7月28日

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  • Pia-Charlotte Stadler,
  • Charlotte Gust,
  • Stefan Weißinger,
  • Lars E. French,
  • Eva M. Oppel

摘要

Allergological emergencies represent a particular challenge in clinical practice, as they require rapid identification and appropriate treatment to prevent serious complications and life-threatening courses. These emergencies primarily include life-threatening systemic hypersensitivity reactions—anaphylaxis—which can manifest on the skin as generalized urticaria and the development of angioedema, as well as severe cutaneous adverse drug reactions (SCADR). Among these, toxic epidermal necrolysis (TEN) represents the most severe one with a mortality rate of up to 30%. In the following article, we will discuss the current state-of-the-art diagnostics and treatment strategies for these dermatological emergencies and highlight new and promising therapeutic approaches.