<p>Disorders of primary hemostasis affect platelet adhesion and aggregation and include von Willebrand disease (vWD), Glanzmann thrombasthenia (GT) and Bernhard-Soulier syndrome (BSS). The safe administration of epidural anesthesia procedures, such as peridural or spinal anesthesia (PDA/SpA) in patients with coagulation disorders requires a thorough weighing-up of the risk of bleeding, especially the risk of spinal epidural hematoma. The adequate management of postpartum hemorrhage (PPH) also requires exact knowledge of the underlying pathophysiology and the available hemostatic treatment options. This article provides an overview of selected hereditary coagulation disorders of primary hemostasis during pregnancy and elucidates the pathophysiological principles, clinical symptoms, diagnostic procedures and treatment strategies.</p>

错误:搜索内容不能为空,请输入英文关键词
错误:关键词超出字数限制,请精简
高级检索

Hereditäre Hämostasestörungen in der Geburtshilfe 1/2 – anästhesiologische Aspekte der primären Hämostase

  • F. Roll,
  • F. Fette,
  • P. Kranke,
  • J. Koscielny,
  • K. Zacharowski,
  • Christian F. Weber,
  • M.-L. Lindner

摘要

Disorders of primary hemostasis affect platelet adhesion and aggregation and include von Willebrand disease (vWD), Glanzmann thrombasthenia (GT) and Bernhard-Soulier syndrome (BSS). The safe administration of epidural anesthesia procedures, such as peridural or spinal anesthesia (PDA/SpA) in patients with coagulation disorders requires a thorough weighing-up of the risk of bleeding, especially the risk of spinal epidural hematoma. The adequate management of postpartum hemorrhage (PPH) also requires exact knowledge of the underlying pathophysiology and the available hemostatic treatment options. This article provides an overview of selected hereditary coagulation disorders of primary hemostasis during pregnancy and elucidates the pathophysiological principles, clinical symptoms, diagnostic procedures and treatment strategies.