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<p>Traditionally, anesthesiology has been a&#xa0;discipline with a&#xa0;broad pharmacological spectrum. In recent years, however, there has been a&#xa0;clear trend toward reducing this range of therapeutic options. Numerous well-established agents have lost importance in many hospitals or have disappeared entirely from the routine clinical practice. This decline is only partly based on new evidence, more often, didactic simplification, cultural standardization, ecological discussions and regulatory interventions by authorities play a&#xa0;decisive role. This article analyzes the causes and mechanisms of this therapeutic impoverishment and compares these developments with other medical disciplines. Finally, it outlines ways in which indication-based, evidence-oriented and differentiated pharmacotherapy in anesthesiology can be strengthened once again.</p>

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Therapeutische Verarmung in der modernen Anästhesiologie – zwischen Sicherheitskultur, Regulatorik und Verlust klinischer Vielfalt

  • 期刊论文

  • 发表日期：

    2026年4月16日

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  • Daniel Chappell,
  • Peter Kranke

摘要

Traditionally, anesthesiology has been a discipline with a broad pharmacological spectrum. In recent years, however, there has been a clear trend toward reducing this range of therapeutic options. Numerous well-established agents have lost importance in many hospitals or have disappeared entirely from the routine clinical practice. This decline is only partly based on new evidence, more often, didactic simplification, cultural standardization, ecological discussions and regulatory interventions by authorities play a decisive role. This article analyzes the causes and mechanisms of this therapeutic impoverishment and compares these developments with other medical disciplines. Finally, it outlines ways in which indication-based, evidence-oriented and differentiated pharmacotherapy in anesthesiology can be strengthened once again.