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Purpose <p>Prehospitally, the paradigm of obliged intubation in traumatic brain injured (TBI) patients with a reduced Glasgow Coma Scale (GCS) &lt; 9 has been debated. Many patients with severe TBI need interhospital transfer to definitive care, so we sought to elucidate possible disadvantages for patients with a reduced level of consciousness where intubation prior transportation was withheld.</p> Methods <p>Transferred patients with at least serious blunt injury to the head (Abbreviated Injury Scale<sub>Head</sub> ≥3) were analyzed. In depth analysis was conducted in patients with GCS 4–9. We applied multivariate regression analysis to search for relevant variables for mortality differences and scrutinized patients who needed immediate intubation upon arrival in the emergency room (ER ITN). In this context a “postponed” intubation refers to an intubation performed upon arrival at the receiving hospital rather than prior to transfer.</p> Results <p>Comparing spontaneously breathing versus already intubated patients (ITN) at admission we did not find statistically significant differences in mortality (33.2% vs. 20.4%; <i>p</i> = 0.067), multiple organ failure (MOF) (37.1% vs. 34%; <i>p</i> = 0.667) or sepsis rates (13.6% vs. 4.2%; <i>p</i> = 0.069). Multiple regression analysis for mortality revealed only age &gt; 70 years, coagulopathy and AIS<sub>Head</sub> ≥ 5 as significantly associated independent variables. But, comparing patients requiring intubation in the emergency room upon admission (ER ITN) to patients already intubated prior transportation (ITN), we detected significant differences in MOF (53.7% vs. 34%; <i>p</i> = 0.025), sepsis (20.5% vs. 4.2%; <i>p</i> = 0.011) and mortality rate (38.1% vs. 20.4%; <i>p</i> = 0.028).</p> Conclusion <p>Our results may suggest an inferior outcome when intubation in patients with GCS 4–9 is needed during admission at the receiving hospital. Further research is warranted to scrutinize optimal airway management for interhospital transfer of TBI patients with reduced GCS.</p>

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Possible detrimental effects of postponed intubation during interhospital transfer of severely brain injured patients: retrospective analysis of the Traumaregister DGU®

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月2日

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  • Ferdinand C. Wagner,
  • Daniel Witry,
  • Rolf Lefering,
  • Christoph Scholz,
  • Hagen Schmal,
  • Jörg Bayer

摘要

Purpose

Prehospitally, the paradigm of obliged intubation in traumatic brain injured (TBI) patients with a reduced Glasgow Coma Scale (GCS) < 9 has been debated. Many patients with severe TBI need interhospital transfer to definitive care, so we sought to elucidate possible disadvantages for patients with a reduced level of consciousness where intubation prior transportation was withheld.

Methods

Transferred patients with at least serious blunt injury to the head (Abbreviated Injury ScaleHead ≥3) were analyzed. In depth analysis was conducted in patients with GCS 4–9. We applied multivariate regression analysis to search for relevant variables for mortality differences and scrutinized patients who needed immediate intubation upon arrival in the emergency room (ER ITN). In this context a “postponed” intubation refers to an intubation performed upon arrival at the receiving hospital rather than prior to transfer.

Results

Comparing spontaneously breathing versus already intubated patients (ITN) at admission we did not find statistically significant differences in mortality (33.2% vs. 20.4%; p = 0.067), multiple organ failure (MOF) (37.1% vs. 34%; p = 0.667) or sepsis rates (13.6% vs. 4.2%; p = 0.069). Multiple regression analysis for mortality revealed only age > 70 years, coagulopathy and AISHead ≥ 5 as significantly associated independent variables. But, comparing patients requiring intubation in the emergency room upon admission (ER ITN) to patients already intubated prior transportation (ITN), we detected significant differences in MOF (53.7% vs. 34%; p = 0.025), sepsis (20.5% vs. 4.2%; p = 0.011) and mortality rate (38.1% vs. 20.4%; p = 0.028).

Conclusion

Our results may suggest an inferior outcome when intubation in patients with GCS 4–9 is needed during admission at the receiving hospital. Further research is warranted to scrutinize optimal airway management for interhospital transfer of TBI patients with reduced GCS.