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Purpose <p>The Masquelet technique is a recent novel treatment for severe bone defects. Polymethylmethacrylate (PMMA) has been used as a spacer for bone defects, but the optimal spacer is still unknown. Therefore, this study aimed to histologically evaluate the membranes induced by bone wax and PMMA spacers and compare them with respect to bone formation.</p> Methods <p>In this study, bone defects were created in the femurs of Sprague–Dawley rats, and bone wax and PMMA spacers were implanted into the defects to histologically evaluate the induced membrane and bone formation after bone grafting.</p> Results <p>As a result, the induced membrane formed by bone wax spacers was significantly thicker than that formed by PMMA spacers, and the vascular area ratio was significantly higher. In addition, bone wax spacers promoted bone formation more than PMMA spacers.</p> Conclusion <p>Bone wax spacers promoted induced membrane formation and bone formation by&#xa0;enhancing inflammatory responses more than PMMA spacers.</p>

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Bone wax spacers increase induced membrane thickness and promote osteogenesis more than polymethylmethacrylate spacers in the masquelet technique

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月27日

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  • Takushi Nakatani,
  • Hajime Mishima,
  • Sho Totsuka,
  • Ryunosuke Watanabe,
  • Norihito Arai,
  • Yohei Tomaru,
  • Hisashi Sugaya,
  • Tomofumi Nishino,
  • Masashi Yamazaki

摘要

Purpose

The Masquelet technique is a recent novel treatment for severe bone defects. Polymethylmethacrylate (PMMA) has been used as a spacer for bone defects, but the optimal spacer is still unknown. Therefore, this study aimed to histologically evaluate the membranes induced by bone wax and PMMA spacers and compare them with respect to bone formation.

Methods

In this study, bone defects were created in the femurs of Sprague–Dawley rats, and bone wax and PMMA spacers were implanted into the defects to histologically evaluate the induced membrane and bone formation after bone grafting.

Results

As a result, the induced membrane formed by bone wax spacers was significantly thicker than that formed by PMMA spacers, and the vascular area ratio was significantly higher. In addition, bone wax spacers promoted bone formation more than PMMA spacers.

Conclusion

Bone wax spacers promoted induced membrane formation and bone formation by enhancing inflammatory responses more than PMMA spacers.