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Purpose <p>Ovarian cancer, one of the most lethal gynecological cancers, metastasizes into skin in 0.9%–5.8% of cases. Cutaneous metastases severely affect the quality of life of ovarian cancer patients. Although cutaneous metastases are rare, a&#xa0;therapeutic option for affected patients is needed. Herein, we present a&#xa0;combination therapy comprising radiation and mild hyperthermia with parallel chemotherapy as a&#xa0;treatment modality.</p> Case <p>A&#xa0;woman with extensive skin metastases of a&#xa0;high-grade, serous ovarian carcinoma on the thigh was treated with a&#xa0;combination of mild hyperthermia (39–43 °C) immediately followed by low-dose hypofractionated radiotherapy and parallel systemic treatment with carboplatin/gemcitabine. Mild hyperthermia, a&#xa0;strong radiosensitizer, was induced through water-filtered infrared A&#xa0;radiation (wIRA).</p> Results <p>The patient responded well and remained tumor free in the treatment area for more than 1&#xa0;year.</p> Conclusion <p>Radiotherapy combined with mild hyperthermia in addition to systemic treatment allows for tumor control in the treated area, even with a&#xa0;reduced total radiation dose. To the best of our knowledge, this is the first report of a&#xa0;long-term tumor-free situation in the treatment area of skin metastases of ovarian cancer. This novel treatment might also be beneficial for skin metastases from other malignancies.</p>

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Management of skin metastases of ovarian cancer: a novel therapeutic approach

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月13日

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  • Anne-Marie Lüchtenborg,
  • Jörg Sahlmann,
  • Kristin Technau-Hafsi,
  • Natalia Volegova-Neher,
  • Beate Rautenberg,
  • Peter Vaupel,
  • Anca-L. Grosu,
  • Andreas R. Thomsen

摘要

Purpose

Ovarian cancer, one of the most lethal gynecological cancers, metastasizes into skin in 0.9%–5.8% of cases. Cutaneous metastases severely affect the quality of life of ovarian cancer patients. Although cutaneous metastases are rare, a therapeutic option for affected patients is needed. Herein, we present a combination therapy comprising radiation and mild hyperthermia with parallel chemotherapy as a treatment modality.

Case

A woman with extensive skin metastases of a high-grade, serous ovarian carcinoma on the thigh was treated with a combination of mild hyperthermia (39–43 °C) immediately followed by low-dose hypofractionated radiotherapy and parallel systemic treatment with carboplatin/gemcitabine. Mild hyperthermia, a strong radiosensitizer, was induced through water-filtered infrared A radiation (wIRA).

Results

The patient responded well and remained tumor free in the treatment area for more than 1 year.

Conclusion

Radiotherapy combined with mild hyperthermia in addition to systemic treatment allows for tumor control in the treated area, even with a reduced total radiation dose. To the best of our knowledge, this is the first report of a long-term tumor-free situation in the treatment area of skin metastases of ovarian cancer. This novel treatment might also be beneficial for skin metastases from other malignancies.