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<p>Patients with left-sided breast cancer receiving radiotherapy are at risk of developing chronic cardiac toxicities. Cardiac dose-sparing techniques such as deep-inspiration breath-hold (DIBH) can reduce this risk. In this study, a&#xa0;model has been developed including tumor localization, left lung volume, and the distance between the heart and medial chest wall as well as age and Eastern Cooperative Oncology Group (ECOG) performance status, which may help to guide the decision for or against DIBH after planning computed tomography (CT) in free breathing directly before initiation of radiotherapy planning.</p>

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Development of a model to guide the decision for radiotherapy in deep-inspiration breath-hold in patients with left-sided breast cancer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月29日

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  • Annett Linge,
  • Carina Ketzmerick,
  • Kristin Gurtner,
  • Cordelia Hoinkis,
  • Steffen Löck,
  • Mechthild Krause

摘要

Patients with left-sided breast cancer receiving radiotherapy are at risk of developing chronic cardiac toxicities. Cardiac dose-sparing techniques such as deep-inspiration breath-hold (DIBH) can reduce this risk. In this study, a model has been developed including tumor localization, left lung volume, and the distance between the heart and medial chest wall as well as age and Eastern Cooperative Oncology Group (ECOG) performance status, which may help to guide the decision for or against DIBH after planning computed tomography (CT) in free breathing directly before initiation of radiotherapy planning.