Scholarlink

<p>Older intensive care unit (ICU) patients are particularly vulnerable to adverse drug reactions, delirium, and treatment failure due to age-related changes in pharmacodynamics (PD) and pharmacokinetics (PK), compounded by the dynamic pathophysiology of critical illness. This review focuses on sedatives/analgesics and anti-infective agents. For analgosedation, an analgesia-first strategy, protocol-based light sedation (awake and cooperative whenever feasible), rigorous delirium management, and avoidance of continuous benzodiazepine infusions are recommended. In anti-infective therapy, key priorities include achieving PK/PD targets, daily dose adjustment to current drug clearance, de-escalation, and early therapeutic drug monitoring (vancomycin, aminoglycosides; selectively also β‑lactams).</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Pharmakodynamik und Pharmakotherapie bei geriatrischen Intensivpatient:innen – Fokus auf Sedativa und Antiinfektiva

  • 期刊论文

  • 发表日期：

    2026年3月12日

查看全文
  • S. Schubert,
  • J. Hähner,
  • Priyanka Böttger,
  • H. Lemm,
  • Michael Buerke

摘要

Older intensive care unit (ICU) patients are particularly vulnerable to adverse drug reactions, delirium, and treatment failure due to age-related changes in pharmacodynamics (PD) and pharmacokinetics (PK), compounded by the dynamic pathophysiology of critical illness. This review focuses on sedatives/analgesics and anti-infective agents. For analgosedation, an analgesia-first strategy, protocol-based light sedation (awake and cooperative whenever feasible), rigorous delirium management, and avoidance of continuous benzodiazepine infusions are recommended. In anti-infective therapy, key priorities include achieving PK/PD targets, daily dose adjustment to current drug clearance, de-escalation, and early therapeutic drug monitoring (vancomycin, aminoglycosides; selectively also β‑lactams).