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Purpose <p>Lesions in the spinal cord (SC) can be found in up to 83% of patients with multiple sclerosis (MS). As they are mainly located in the cervical segment, many centers exclude the thoracic part from SC imaging. The aim of our study was to quantify the decrease in sensitivity resulting from this approach.</p> Methods <p>MR images (3T) of 543 consecutive patients with clinically isolated syndrome (CIS) (<i>n</i>: 37) and MS (<i>n</i>: 506) were analyzed retrospectively. Lesions were segmented semi-automatically on axial T2-weighted images of the whole SC using BrainSeg3D. The volume of lesions was related to vertebral levels.</p> Results <p>Altogether 1782 lesions (CIS: 19; MS: 1763) were found in 409 patients. 70% of the lesion volume was located in the SC above the 3rd thoracic vertebral body, in a segment that is commonly covered by an isolated examination of the cervical SC. However, 26 patients (6%) showed lesions exclusively below the 3rd thoracic vertebral body, thus 94% of all patients with SC lesions could be detected with isolated MR imaging of the cervical SC.</p> Conclusion <p>Though the majority of lesions can be detected in an isolated examination of the upper part of the SC, some patients showed lesions exclusively below the 3rd thoracic vertebral body. We recommend routine scanning of the whole SC in suspected MS.</p>

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Is MR Imaging of the Cervical Spinal Cord Sufficient for Patients with Suspected Multiple Sclerosis?

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月21日

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  • Isabelle Riederer,
  • Matthias Bussas,
  • Markus Lauerer,
  • Laura Harabacz,
  • Viktor Pineker,
  • Malek El Husseini,
  • Nico Sollmann,
  • Claus Zimmer,
  • Jan S. Kirschke,
  • Mark Mühlau

摘要

Purpose

Lesions in the spinal cord (SC) can be found in up to 83% of patients with multiple sclerosis (MS). As they are mainly located in the cervical segment, many centers exclude the thoracic part from SC imaging. The aim of our study was to quantify the decrease in sensitivity resulting from this approach.

Methods

MR images (3T) of 543 consecutive patients with clinically isolated syndrome (CIS) (n: 37) and MS (n: 506) were analyzed retrospectively. Lesions were segmented semi-automatically on axial T2-weighted images of the whole SC using BrainSeg3D. The volume of lesions was related to vertebral levels.

Results

Altogether 1782 lesions (CIS: 19; MS: 1763) were found in 409 patients. 70% of the lesion volume was located in the SC above the 3rd thoracic vertebral body, in a segment that is commonly covered by an isolated examination of the cervical SC. However, 26 patients (6%) showed lesions exclusively below the 3rd thoracic vertebral body, thus 94% of all patients with SC lesions could be detected with isolated MR imaging of the cervical SC.

Conclusion

Though the majority of lesions can be detected in an isolated examination of the upper part of the SC, some patients showed lesions exclusively below the 3rd thoracic vertebral body. We recommend routine scanning of the whole SC in suspected MS.