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Purpose <p>Intracranial aneurysms are a&#xa0;major cause of hemorrhagic stroke, often requiring endovascular intervention. The Woven EndoBridge (WEB) device offers a&#xa0;minimally invasive solution for wide-neck bifurcation aneurysms and typically requires only single antiplatelet therapy, reducing bleeding risks associated with dual regimens. However, long-term clinical and angiographic data remain limited.</p> Methods <p>This single-center, retrospective study analyzed 247 patients treated with the WEB device between January 2013 and December 2021, with clinical and imaging follow-up through June 2024. Demographics, aneurysm characteristics, procedural outcomes, and retreatment rates were evaluated. A&#xa0;competing risk model was applied to identify factors associated with retreatment.</p> Results <p>The cohort included 247 patients (mean age: 63&#xa0;years; 70% female) with 266 broad-based intracranial aneurysms. The overall retreatment rate was 12.8%, most occurring within the first year. Subgroup analysis revealed no significant differences based on aspect ratio (&lt; 1.6 vs. ≥ 1.6) or device diameter (&lt; 0.9 mm vs. ≥ 0.9 mm). Patients treated after 2018 had significantly lower retreatment rates (HR: 0.31; 95% CI: 0.13–0.71; <i>p</i> = 0.006), likely reflecting greater operator experience and introduction of the WEB17 model.</p> Conclusion <p>The WEB device demonstrates durable aneurysm occlusion with a&#xa0;low long-term retreatment rate. Improved outcomes after 2018 suggest an effect of the learning curve and device refinement. Early imaging follow-up and continued operator training remain essential to optimize procedural success.</p>

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Long-Term Follow-up of the Woven EndoBridge (WEB) Device for the Treatment of Broad Based Intracranial Aneurysms: A Single-Center Retrospective Observational Analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月5日

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  • Humberto Abraham Cortés Magdaleno,
  • Ansgar Berlis,
  • Guilherme Quint,
  • Mahmoud Zaki,
  • Christoph Maurer

摘要

Purpose

Intracranial aneurysms are a major cause of hemorrhagic stroke, often requiring endovascular intervention. The Woven EndoBridge (WEB) device offers a minimally invasive solution for wide-neck bifurcation aneurysms and typically requires only single antiplatelet therapy, reducing bleeding risks associated with dual regimens. However, long-term clinical and angiographic data remain limited.

Methods

This single-center, retrospective study analyzed 247 patients treated with the WEB device between January 2013 and December 2021, with clinical and imaging follow-up through June 2024. Demographics, aneurysm characteristics, procedural outcomes, and retreatment rates were evaluated. A competing risk model was applied to identify factors associated with retreatment.

Results

The cohort included 247 patients (mean age: 63 years; 70% female) with 266 broad-based intracranial aneurysms. The overall retreatment rate was 12.8%, most occurring within the first year. Subgroup analysis revealed no significant differences based on aspect ratio (< 1.6 vs. ≥ 1.6) or device diameter (< 0.9 mm vs. ≥ 0.9 mm). Patients treated after 2018 had significantly lower retreatment rates (HR: 0.31; 95% CI: 0.13–0.71; p = 0.006), likely reflecting greater operator experience and introduction of the WEB17 model.

Conclusion

The WEB device demonstrates durable aneurysm occlusion with a low long-term retreatment rate. Improved outcomes after 2018 suggest an effect of the learning curve and device refinement. Early imaging follow-up and continued operator training remain essential to optimize procedural success.