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Background <p>The human microbiome is a&#xa0;complex ecosystem that has a&#xa0;significant impact on health. Dysbiosis, an imbalance in microbial communities, is often associated with various diseases and could therefore be a&#xa0;target for therapeutic interventions and preventive measures.</p> Objectives <p>The aim of this article is to critically examine the concept of dysbiosis and to present concepts and supportive measures for promoting a&#xa0;healthy intestinal microbiome.</p> Materials and methods <p>This is a&#xa0;narrative review that summarizes and critically evaluates current scientific literature on the microbiome, dysbiosis, nutrition, lifestyle, and probiotic interventions.</p> Results <p>The term “dysbiosis” is not clearly defined scientifically and therefore does not always imply functional and health-relevant changes in the microbiome. The composition of the microbiome is significantly influenced by diet, physical activity, and environmental factors. Plant-based foods, polyphenols, and fermented products promote microbial diversity and in addition the production of short-chain fatty acids, which modulate inflammatory and metabolic processes. Regular physical activity also increases diversity and supports metabolic resilience.</p> Conclusion <p>Promoting a&#xa0;health-associated microbiome requires an integrative approach combining diet, exercise, and, if necessary, targeted microbial modulation.</p>

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Supportive Therapie der Dysbiose

  • 期刊论文

  • 发表日期：

    2026年2月10日

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  • Ann-Kathrin Lederer,
  • Nele Görrissen,
  • Alexandra C. Klein,
  • Roman Huber,
  • Mohamed Tarek Badr

摘要

Background

The human microbiome is a complex ecosystem that has a significant impact on health. Dysbiosis, an imbalance in microbial communities, is often associated with various diseases and could therefore be a target for therapeutic interventions and preventive measures.

Objectives

The aim of this article is to critically examine the concept of dysbiosis and to present concepts and supportive measures for promoting a healthy intestinal microbiome.

Materials and methods

This is a narrative review that summarizes and critically evaluates current scientific literature on the microbiome, dysbiosis, nutrition, lifestyle, and probiotic interventions.

Results

The term “dysbiosis” is not clearly defined scientifically and therefore does not always imply functional and health-relevant changes in the microbiome. The composition of the microbiome is significantly influenced by diet, physical activity, and environmental factors. Plant-based foods, polyphenols, and fermented products promote microbial diversity and in addition the production of short-chain fatty acids, which modulate inflammatory and metabolic processes. Regular physical activity also increases diversity and supports metabolic resilience.

Conclusion

Promoting a health-associated microbiome requires an integrative approach combining diet, exercise, and, if necessary, targeted microbial modulation.