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<p>The Nazarov cyclization has evolved from a traditional acid-driven electrocyclization into a flexible synthetic platform. This review summarizes its transformation through a strategic framework centered on three control points: initiation, diverting, and stereochemistry. Modern initiation strategies (substrate pre‑activation, cooperative catalysis, photochemical excitation) replace harsh acids; diverting the oxyallyl cation delivers complex structures via intra‑ or intermolecular trapping; and stereochemical control ranges from chiral auxiliaries to novel catalytic systems. Key advances are illustrated through natural product syntheses.</p><p></p>

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Taming the reactive intermediates: the nazarov cyclization as a programmable platform

  • 期刊论文

  • 发表日期：

    2026年7月31日

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  • Yunfei Cheng,
  • Ye Yuan,
  • Qun Sun

摘要

The Nazarov cyclization has evolved from a traditional acid-driven electrocyclization into a flexible synthetic platform. This review summarizes its transformation through a strategic framework centered on three control points: initiation, diverting, and stereochemistry. Modern initiation strategies (substrate pre‑activation, cooperative catalysis, photochemical excitation) replace harsh acids; diverting the oxyallyl cation delivers complex structures via intra‑ or intermolecular trapping; and stereochemical control ranges from chiral auxiliaries to novel catalytic systems. Key advances are illustrated through natural product syntheses.