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<p>A new cytosporin derivative, cytoeutypellane D, was isolated from a culture extract of the Arctic-derived fungus <i>Eutypella</i> sp. D-1. Its structure was determined based on a detailed nuclear magnetic resonance spectroscopic interpretation, a mass spectrometry data analysis, and a literature review. Zebrafish were used in in vivo experiments to discover that the isolated compound significantly promoted angiogenesis in a dose-dependent manner. Further studies regarding the underlying mechanisms revealed that it may target the VEGF/VEGFR2 signaling pathway and rescue abnormal expressions of the <i>cdk1</i>, <i>aurkb</i>, <i>topbp1</i>, and <i>brca2</i> genes to improve vascular endothelial cell proliferation and migration in zebrafish. In summary, our findings suggested that this novel compound isolated from the fungus <i>Eutypella</i> sp. D-1 might be used as a promising molecule for vascular injury disease treatment.</p><p></p>

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Proangiogenic effect and molecular mechanism of a new cytosporin derivative from the marine fungus Eutypella sp. D-1

  • 期刊论文

  • 发表日期：

    2026年4月7日

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  • Xiaoyue Sun,
  • Ranran Zhu,
  • Qijia Feng,
  • Peihai Li,
  • Yun Zhang,
  • Qing Xia,
  • Kechun Liu,
  • Xuehui Jian,
  • Yuanshuai YU,
  • Xue Wang,
  • Chen Sun,
  • Haobing YU

摘要

A new cytosporin derivative, cytoeutypellane D, was isolated from a culture extract of the Arctic-derived fungus Eutypella sp. D-1. Its structure was determined based on a detailed nuclear magnetic resonance spectroscopic interpretation, a mass spectrometry data analysis, and a literature review. Zebrafish were used in in vivo experiments to discover that the isolated compound significantly promoted angiogenesis in a dose-dependent manner. Further studies regarding the underlying mechanisms revealed that it may target the VEGF/VEGFR2 signaling pathway and rescue abnormal expressions of the cdk1, aurkb, topbp1, and brca2 genes to improve vascular endothelial cell proliferation and migration in zebrafish. In summary, our findings suggested that this novel compound isolated from the fungus Eutypella sp. D-1 might be used as a promising molecule for vascular injury disease treatment.