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<p>Cytochrome P450s (CYP450s) are a diverse and functionally rich family of heme-containing enzymes that play vital roles in the metabolism of endogenous and xenobiotic compounds. In recent years, microbial CYP450s have gained attention for their potential in environmental bioremediation due to their ability to oxidize a wide range of chemically complex and recalcitrant pollutants. This mini-review provides an overview of CYP450s and highlights their emerging roles in the degradation of selected environmental pollutants, including pharmaceuticals, personal care products (PPCPs), polycyclic aromatic hydrocarbons (PAHs), and polychlorinated biphenyls (PCBs). We further discuss recent advances in CYP450 discovery enabled by metagenomic mining, sequence similarity networks, and machine learning/artificial intelligence (ML/AI), along with innovations in enzyme engineering through rational design, site-directed mutagenesis, and ML/AI-guided directed evolution. Collectively, these developments illustrate the growing potential of microbial CYP450s as sustainable biocatalysts for tackling complex environmental contaminants.</p><p></p>

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Biocatalytic potential of microbial CYP450s in the degradation of selected environmental pollutants

  • 期刊论文

  • 发表日期：

    2025年8月18日

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  • Vanisa Petriti,
  • Amit Mondal,
  • Yousong Ding

摘要

Cytochrome P450s (CYP450s) are a diverse and functionally rich family of heme-containing enzymes that play vital roles in the metabolism of endogenous and xenobiotic compounds. In recent years, microbial CYP450s have gained attention for their potential in environmental bioremediation due to their ability to oxidize a wide range of chemically complex and recalcitrant pollutants. This mini-review provides an overview of CYP450s and highlights their emerging roles in the degradation of selected environmental pollutants, including pharmaceuticals, personal care products (PPCPs), polycyclic aromatic hydrocarbons (PAHs), and polychlorinated biphenyls (PCBs). We further discuss recent advances in CYP450 discovery enabled by metagenomic mining, sequence similarity networks, and machine learning/artificial intelligence (ML/AI), along with innovations in enzyme engineering through rational design, site-directed mutagenesis, and ML/AI-guided directed evolution. Collectively, these developments illustrate the growing potential of microbial CYP450s as sustainable biocatalysts for tackling complex environmental contaminants.