<p>The sustainability of the Nile Delta is threatened by urban expansion, water scarcity, pollution, and climate change. However, there is a lack of comprehensive, data-driven syntheses that map research trends, identify gaps, and outline prospects for this region. To the best of our knowledge, this review is the first comprehensive effort to address this critical information gap. Given the challenges confronting the Nile Delta, this review presents a systematic bibliometric analysis and a strengths, weaknesses, opportunities, and threats analysis of sustainability research undertaken in the region. It highlights critical knowledge gaps, including a lack of information on climate adaptation and pollution management for the region, and outlines a roadmap for future interdisciplinary research and technological innovation. The integration of bibliometric mapping, statistical gap analysis, and artificial intelligence-based environmental monitoring is used to generate actionable insights and a forward-looking vision for the sustainable management of this region. This vision emphasizes adaptive water resource management to address freshwater scarcity, salinisation, and pollution, and thus aligns with the agenda of Egypt's Vision 2030 and the United Nations Sustainable Development Goals for a green economic transition. The recommendations given in this review for the sustainable development of the Nile Delta emphasize the need for integrated coastal zone management. The most critical measures that need to be undertaken include enhancing the monitoring of infrastructure and implementing climate adaptation strategies. Urban and industrial planning must incorporate vulnerability assessments and risk mitigation. Water quality improvement efforts should focus on wastewater treatment, nutrient reduction, and sustainable management of the Nile River. Integrated water resource management and forecasting systems, supported by comprehensive datasets and policy interventions, are essential for this.</p>